肝硬化门静脉高压患者血清胃蛋白酶原Ⅰ与胃蛋白酶原Ⅱ水平的变化及其临床意义

摘要

目的 探讨血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)在肝硬化门静脉高压中的临床意义.方法 选取肝硬化门静脉高压症患者93例(观察组),同时选取选取健康体检者90例作为对照组,采用酶联免疫吸附试验检测两组血清PG Ⅰ和PGⅡ水平.结果 观察组血清PG Ⅰ和PGⅡ分别为(160.31±21.06)μ∥L和(17.32±1.63) μg/L,明显高于对照组,差异有统计学意义(P＜0.05);Child-Paugh C级患者PG Ⅰ和PGⅡ分别为(201.16±32.11)μg/L和(30.21±2.32) μg/L,明显高于A级和B级患者(P＜0.05);门静脉主干内径＞13 mm患者PG Ⅰ和PGⅡ分别为(184.22±27.06) μg/L和(21.06±1.42)μg/L,明显高于≤13 mm患者,差异有统计学意义(P＜0.05).结论 肝硬化门脉高压症患者血清PG Ⅰ和PGⅡ水平升高,与肝功能分级以及肝脏门静脉主干内径有一定的相关性.%Objective To investigate clinical significance of the serum pepsinogen Ⅰ (PG Ⅰ),pepsinogen Ⅱ (PG Ⅱ) in patients with hepatic cirrhosis and portal hypertension.Methods 93 patients (observation group) with cirrhosis and portal hypertension were selected in our hospital,and 90 healthy persons as control group,enzyme linked immunosorbent assay was used to detect the levels of serum PG Ⅰ and PG Ⅱ in the two groups.Results The serum levels ofPG Ⅰ and PG Ⅱ in observation group were (160.31 ± 21.06) g/L and (17.32 ± 1.63) g/L,significantly higher than the control group,the difference was statistically significant (P ＜ 0.05);The Child-Paugh grade C patients PG Ⅰ and PG Ⅱ were (201.16 ± 32.11) g/L and (30.21 ± 2.32) g/L was significantly higher than that of Grade A and B patients (P ＜ 0.05).The inner diameter of the main portal vein ＞ 13 mm patients with PG Ⅰ and PG Ⅱ were tested (184.22 ± 27.06) g/L and (21.06 ± 1.42) g/L,were significantly higher than that of ≤13 mm patients,the difference was statistically significant (P ＜ 0.05).Conclusion The serum levels of PG Ⅰ and PG Ⅱ are higher in the patients with cirrhosis and portal hypertension,it may be related to the liver function grade and the inner diameter of the main portal vein of the liver.