赛胃安胶囊在反流性食管炎中的疗效观察

摘要

[目的]观察赛胃安胶囊对反流性食管炎的疗效。[方法]80例反流性食管炎患者按入组先后分为治疗组、对照组，每组40例。对照组予以耐信＋莫沙必利治疗，治疗组在对照组治疗的基础上加服赛胃安胶囊。比较2组患者治疗1周、8周后临床症状变化，同时比较治疗8周后内镜下食管炎改善情况。[结果]治疗1周后，治疗组临床症状改善为显效31例、有效8例、无效1例，总有效率为97.5％；对照组显效23例、有效12例、无效5例，总有效率87.5％；治疗组疗效优于对照组，差异有统计学意义（ P＜0.05）。治疗8周后，治疗组显效37例、有效3例、无效0例，总有效率100％；对照组显效34例、有效4例、无效2例，总有效率95.0％；治疗组疗效优于对照组，但差异无统计学意义（ P＞0.05）。治疗8周后反流性食管炎恢复情况，治疗组显效33例、有效5例、无效2例，总有效率95.0％；对照组显效24例、有效12例、无效4例，总有效率90.0％；治疗组明显优于对照组（ P＜0.05）。[结论]赛胃安胶囊能促进反流性食管炎的愈合，并有助于改善反流性食管炎的临床症状。%Objective]To evaluate the efficacy of Saiweian Capsule in treating reflux esophagitis. [Meth‐ods]Eighty patients were divided into two groups 40 cases treated with Nexium + mosapride + Saiweian Capsule(group A) ,40 cases treated with Nexium + mosapride(group B). The clinical symptoms between group A and group B after 1 week and after 8 weeks of treatment were compared. The change of endoscopic reflux esophagitis after 8 weeks of treatment was also compared. [Results]After 1 week treatment ,the change of clinical symptoms of group A was 31 cases apparent ,6 cases effective ,1 case invalid ,group B was 23 cases apparent ,12 cases effective ,5 cases invalid. The response of group A was more obvious than group B with statistical difference(P<0.05).After 8 weeks treatment the change of clinical symptoms of group A was 37 cases apparent ,3 cases effective ,0 cases invalid ,while the resulf of group B was 34 cases appar‐ent ,4 cases effective ,2 cases invalid .The result of group A was slightly better than group B with no statis‐tical difference(P>0.05). The change of endoscopic reflux esophagitis in group A was 33 cases apparent ,5 cases effective ,2 cases invalid ,group B was 24 cases apparent ,12 cases effective ,4 cases invalid ,the result of group A was much better than group B ,there was statistical difference(P<0.05). [Conclusion]Saiweian Capsule can promote the healing of reflux esophagitis ,and may contribute to the improvement of clinical symptoms of reflux esophagitis.