组织细胞坏死性淋巴结炎中CD123及MPO的表达及意义

摘要

Purpose To investigate the expression of CD123 and MPO in histiocytic necrotizing lymphadenitis ( HNL ) and the sensitivity and specificity of CD123 in the identifying HNL from other diseases. Methods Immunohistochemical staining for CD123 and MPO was earned out on a series of 39 HNL, 14 reactive lymphoid hyperplasia ( RLH ) and 12 diffuse large B-cell lymphoma ( DL-BCL ). Results The expression rate of CD123 was 89. 7% in HNL, 33. 3% in RLH ( P <0. 01 ) and 16. 7% in DLBCL( P <0. 01 ). The sensitivity and speicificity of CD123 was 90% and 75% , and MPO was 82% and 88% , respectively. The sensitivity and specificity of the combination of CD123 and MPO was 79% and 96% . Conclusion CD123 and MPO have a high sensitivity and specificity in the diagnosis and differential diagnosis of HNL, both of them are useful immunohisitochemical markers for HNL.%目的 探讨CD123和MPO在组织细胞坏死性淋巴结炎(histiocytic necrotizing lymphadenitis,HNL)中的表达及在诊断和鉴别诊断中的价值.方法 对39例HNL进行常规形态学观察和免疫组化标记,12例淋巴组织反应性增生性病变和12例弥漫性大B细胞淋巴瘤作为对照.结果 CD123在HNL中的阳性率为89.7%,淋巴组织反应性增生性病变中的阳性率为33.3%(P<0.01),弥漫性大B细胞性淋巴瘤中的阳性率为16.7%(P<0.01),其CD123敏感性为90%,特异性为75%;MPO的敏感性为82%,特异性为88%,两者联合应用,其敏感性为79%,特异性为96%.结论 CD123和MPO在HNL中均具有较高的阳性率,其敏感性和特异性均较好,具有很好的诊断和鉴别诊断价值,是诊断HNL较为理想的免疫标记物.