磺化聚醚砜提高聚醚砜膜亲水性和血液相容性研究

摘要

PolyethersulfoRe(PES)iS widely used as biomaterials due to its thermal stabilitY,mechanical strength,and chemicaIincrtncss.Nevertheless.their blood compatibility iS still not adequate for hemodialysis and blood purification.In this study,the sulfohated polyethcrsulfone(SPES)was synthesized through an electrophilic substitution reaction,and PES/SPES blending membranes wcre prepared.The characterization of the SPES was studied by FTIR.The water adsorption and water contact angle experiments show that the hydrophilicity of PES/SPES blend membrane was improved as for the sulfonate group existing in the SPES.Moreover.PES/SPES blend membrane could ciTectively reduce bovine serum albumin adsorption and prolong the blood coagulation time compared with the PES membrane,thereby improving blood compatibility.