Objective :To explore influence of sodium creatine phosphate (CP) on percutaneous coronary intervention (PCI)-related myocardial injury in patients with unstable angina pectoris (UAP).Methods : A total of 90 UAP pa-tients ,who were supposed to receive selective PCI ,were selected ,randomly and equally divided into routine treat-ment group and CP group (received CP treatment based on routine medication ).Plasma level of cardiac troponin I (cTnI) before and 18h after PCI ,plasma levels of C reactive protein (CRP) and brain natriuretic peptide (BNP) be- fore and 24h after PCI ,LVEDd ,LVESd and LVEF on two weeks after PCI ,and incidence of major adverse cardio-vascular events (MACE) within two weeks after PCI were measured and compared between two groups .Results :Compared with before PCI ,there was significant rise in plasma cTnI level on 18h after PCI ,and significant reduc-tions in plasma CRP and BNP levels on 24h after PCI in two groups ,P＝0-001 all ;compared with routine treatment group after PCI ,there were significant reductions in plasma levels of cTnI [ (1-58 ± 1-59) mg／L vs.(0-07 ± 0-04) mg／L] ,CRP [ (22-02 ± 2-14) ng／L vs .(11-40 ± 1-49) ng／L] and BNP [ (349-20 ± 28-57) ng／L vs .(175-20 ± 28-55) ng／L] in CP group , P＝0-001 all.Compared with routine treatment group ,there were significant reduc-tions in LVEDd [ (54-83 ± 1-23) mm vs.(50-74 ± 0-97) mm] and LVESd [ (45-65 ± 1-64) mm vs .(42-01 ± 1-84) mm] ,and significant rise in LVEF [ (52-41 ± 1-57)% vs.(65-21 ± 3-36)%] in CP group on two weeks af-ter PCI , P＝0-001 all.On two weeks after PCI ,incidence rate of MACE in CP group was significantly lower than that of routine treatment group (4-44% vs.28-89%) , P＝0-021- Conclusion : CP can significantly reduce plasma levels of cTnI ,CRP and BNP after PCI ,reduce PCI-related myocardial injury .%目的:探讨磷酸肌酸(CP)钠对不稳定型心绞痛(UAP)患者经皮冠脉介入治疗(PCI)相关心肌损伤的影响.方法:选择拟进行择期PCI术的UAP患者90例.患者被随机均分为常规治疗组和CP组(常规药物治疗基础上接受CP治疗).测量比较两组术前,术后18h血浆心肌肌钙蛋白 I (cTnI)、术前,术后24h血浆C反应蛋白(CRP)和脑钠肽(BNP)水平,术后2周 LVEDd 、 LVESd和 LVEF ,以及术后2周内的主要不良心血管事件(MACE)发生情况.结果:与术前比较,术后18h两组血浆cTnI水平显著升高,术后24h血浆CRP和BNP水平均显著降低, P均＝0-001 ;且与常规治疗组比较, CP组术后血浆cTnI [ (1-58 ± 1-59 ) mg／L比(0-07 ± 0-04) mg／L] 、 CRP [ (22-02 ± 2-14) ng／L比(11-40 ± 1-49 ) ng／L]和BNP [ (349-20 ± 28-57) ng／L比(175-20 ± 28-55) ng／L]水平显著降低, P均＝0-001 .与常规治疗组比较,术后2周CP组LVEDd [ (54-83 ± 1-23) mm比(50-74 ± 0-97) mm]和LVESd [ (45-65 ± 1-64) mm比(42-01 ± 1-84) mm]显著降低, LVEF [ (52-41 ± 1-57)% 比(65-21 ± 3-36)%]显著升高, P均＝0-001 .术后2周, CP组的MACE发生率显著低于常规治疗组(4-44% 比28-89%) , P＝0-021 .结论:磷酸肌酸钠能显著降低不稳定型心绞痛患者PCI术后血浆cTnI 、 CRP 、BNP水平,减少手术相关的心肌损伤.
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