老年高血压病人心血管内分泌激素与胰岛素抵抗作用的探讨

摘要

目的：探讨老年高血压病人的心血管内分泌激素与胰岛素抵抗的关系。方法：对老年Ⅰ、Ⅱ期高血压病人40例与健康对照组30例测定了血清(血浆)t-PA、PAI活性，ANP、ET、A Ⅰ、A Ⅱ水平，分析了胰岛素敏感性(IS)与纤溶活性、BMI、ANP、ET、A Ⅱ、BP的相关性。结果：老年高血压组PAI、ANP、ET、A Ⅱ、总胆固醇、甘油三酯水平明显高于健康对照组，而t-PA、IS水平则明显低于健康对照组。结论：心血管内分泌激素与胰岛素抵抗在老年高血压病人的发生、发展中起着极为重要的作用。%Objective: To research the effects of cardiovascular endocrine hormone and insulin-resistance in aged patients with hypertension. Methods: The t-PA of serum (plasma), activity of PAI、 ANP、 ET、 A Ⅰ 、 A Ⅱ and IR were determined in 40 patients with Ⅰ and Ⅱ stage of hypertension and in 30 healthy subjects (control group). Results: The PAI、 ANP 、 ET、 A Ⅱ and total cholesterol and triglyceride levels were apparently higher in patients with hypertension than in healthy control group. The t-PA and IS were obviously lower in hypertensive patients than in healthy control group. Conclusion:The cardiovascular endocrine hormone and insulin-resistance play an important role in genesis and development of hypertension in aged.