磷酸肌酸对早期舒张功能障碍的疗效

摘要

Objective: To investigate the therapeutic effect of creatine phosphate sodium (CP,Neoton) at early stage of myocardium diastolic dysfunction.Methods:A total of 138 cases with myocardium diastolic dysfunction were divided into CP group (n=109) and routine treatment group (n=29). All the patients received routine treatment. The CP group received CP treatment based on routine treatment(CP 2g+5%glucose or 0.9% sodium chloride 100ml, iv. drip, for patients with mild diastolic dysfunction was 1time/d, patients with moderate diastolic dysfunction was 2 times/d), duration was 7-14 days. Color-coded Doppler echocardiography was used to detect transmitral peak early diastolic velocity (E-wave),transmitral peak late diastolic velocity (A-wave),peak early diastolic velocity of mitral annulus (Ea), and peak late diastolic velocity of mitral annulus(Aa), and the value of E/A ,Ea/Aa and E/Ea were calculated. Symptoms, signs and items from echocardiography were compared between the two groups before and after treatment. Results:After treatment, all symptoms and signs of patients in two groups significantly improved (P<0.05～0.01), and the marked effective rate in CP group was significantly higher than that of routine treatment group (96.2% vs. 57.1%, P<0.01). In CP group, the marked effective rate of E/A (81.65% vs. 10.34%), Ea/Aa (83.49% vs. 13.79%) and E/Ea (92.86% vs. 12.00%) were significantly higher than those in routine treatment group (P<0.01all).Conclusion:Creatine phosphate possesses marked effect for improving patient's condition and diastolic dysfunction.%目的:探讨磷酸肌酸钠(CP,里尔统)治疗心肌早期舒张功能障碍的疗效.方法:心肌舒张功能障碍患者138例,分为磷酸肌酸钠组(109例)常规治疗组(29例),所有患者均进行常规治疗.磷酸肌酸组在常规治疗的基础上,给予CP 2g+5%葡萄糖或0.9%的氯化钠100ml静脉滴注,轻度舒张功能减低者每天1次,中度舒张功能减退者每天2次,连续7～14d为1疗程.采用彩色多普勒超声心动图检测二尖瓣口舒张早期峰值流速(E)、二尖瓣口舒张晚期峰值流速(A),二尖瓣环舒张早期速度峰值(Ea)、二尖瓣环舒张晚期速度峰值(Aa),计算E/A比值,Ea/Aa比值和E/Ea比值,对比治疗前后两组临床症状、体征及彩色多普勒超声心动图各指标改善情况.结果:治疗后两组患者所有症状和体征均有明显的改善(P<0.05～0.01),且磷酸肌酸钠组临床显效率(96.2%)明显高于常规治疗组的57.1%(P<0.01).磷酸肌酸钠组E/A比值(81.65%:10.34%)、Ea/Aa比值(83.49%:13.79%)、E/Ea比值(92.86%:12.00%)的显效率均显著高于常规治疗组的(P均<0.01).结论:磷酸肌酸钠对于改善心脏舒张功能和病情有显著疗效.