胱抑素C与主动脉夹层的相关性研究

摘要

Objective: To investigate the relationship between serum level of cystatin C and aortic dissection (AD). Methods-. A total of 45 AD cases diagnosed by computed tomography for angiography (CTA) or magnetic resonance imaging (MRI) were enrolled as AD group. Another 45 cases without AD and with corresponding gender ratio, age and body mass index (BMD to AD group were selected as control group. Particle-enhanced immunoturbidimetry was used to measure plasma levels of cystatin C of the two groups and they were compared then. Relationship among plasma level of cystatin C, other risk factors and AD was analyzed by Logistic regression analysis. Results: Plasma level of cystatin C was significantly higher in AD group than that of control group [ (1. 93 ± 0. 59) mg/L vs. (1. 12±0. 31) mg/L, P＜0. 05]. Logistic regression analysis indicated that plasma level of cystatin C was significantly positively correlated with AD (OR=2. 833, P＜0. 01). Conclusion: Plasma level of cystatin C is closely correlated with aortic dissection and it is a risk factor of aortic dissection.%目的:研究半胱氨酸蛋白酶抑制剂-胱抑素C与主动脉夹层的相关性.方法:选择经计算机断层血管摄影术(CTA)或核磁共振成像(MRI)确诊的主动脉夹层患者45例,收集性别、年龄、体重指数(BMI)等与主动脉夹层组相匹配的非主动脉夹层者45例为对照组,采用颗粒增强免疫比浊法测定血浆胱抑素C水平,比较两组间胱抑素C水平差异,应用Logistic回归比较胱抑素C及其他危险因素与主动脉夹层的关系.结果:主动脉夹层组血浆胱抑素C水平明显高于正常对照组[(1.93±0.59)mg/L∶(1.12±0.31) mg/L,P<0.05],Logistic回归分析结果显示,胱抑素C与主动脉夹层显著相关(OR= 2.833,P< 0.01).结论:胱抑素C与主动脉夹层密切相关,是主动脉夹层的危险因素.