Objective: To investigate correlation between plasma level of hydrogen sulfide (H2S) and incidence of hypertension in people with high normal blood pressure. Methods: Clinical data of 1 056 subjects with high normal blood pressure undergoing health examination were retrospectively analyzed. Deproteinization method was used to measure plasma H2S concentration. After 24 - month follow up, according to develop into hypertension or not, subjects were divided into hypertension group (n = 226) and no-hypertension group (n= 830). Plasma H2S level was compared between the two groups. Quartile method was used to analyze relation between H2S concentration and incidence rate of hypertension; Logistic regression analysis was used to study whether H2S level was a risk factor for incidence of hypertension. Results; Plasma H2S concentration of hypertension group was significantly lower than that of no-hypertension group [ (32.54 ±3. 61) μmol/L vs. (50. 62 ± 3. 84) μmol/L, P<0.01] ; the lower H2S concentration was (<60. 72μmol/L, <51. 84μmol/L. <42. 97μmol/L, <34. 09μmol/L), the higher incidence rate of hypertension was (13.3%, 15.0% , 27.8%, 35.8%, P<0.01)j Logistic regression analysis indicated that plasma H2S concentration was a risk factor of hypertension (OR = 2.821, P<.0.001). Conclusion: Decrease of plasma concentration of hydrogen sulfide may be a risk factor makeing people with high normal blood pressure develop into hypertension patient.%目的:研究正常高值血压人群血浆硫化氢(H2S)水平与其高血压发生的相关性.方法:回顾性分析1056例参加健康查体的正常高值血压者,去蛋白法检测血浆H2S含量;随访24个月后,按是否进展为高血压分为高血压组(226例)和无高血压组(830例),比较两组间血浆H2S水平差异;四分位法分析H2S含量与高血压发生率的关系;Logistic回归分析法研究H2S水平是否为高血压发生的危险因素.结果:高血压组血浆H2S含量明显低于无高血压组[(32.54±3.61)μmol/L比(50.62±3.84)μmol/L,P＜0.01];随H2S含量逐渐降低(＜60.72μmol/L,＜51.84μmol/L,＜42.97μmol/L,＜34.09μmol/L),高血压发生率逐渐升高(13.3％,15.0％,27.8％,35.8％,P＜0.01); Logistic回归分析显示血浆H2S含量是导致高血压发生的危险因素(1R=2.821,P＜0.001).结论:血浆硫化氢含量降低,可能是促进正常高值血压者向高血压进展的危险因素.
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