Firebird 支架联合替罗非班用于急性心肌梗死中的疗效及安全性

摘要

目的：评价Firebird支架联合替罗非班用于急性心肌梗死（AMI）中的疗效及安全性。方法：选择2011年8月至2013年8月我院收治的86例AMI患者，依据随机数字表法患者被分为：联合治疗组（50例， Firebird支架联合替罗非班）和常规治疗组（36例，裸金属支架）。对患者进行12～18个月的随访，比较两组临床疗效、临床事件发生率。结果：PCI术后，与常规治疗组比较，联合治疗组患者TIMI分级1－2级比例（13.9％比4.0％）明显减少，3～4级比例（86.1％比96.0％）明显增加，校正TIMI计帧数[（29.2±4.4）比（21.4±5.1）]明显减少， P均＜0.05；术后6个月，与常规治疗组比较，联合治疗组的亚急性血栓（2.8％比0％）、心肌梗死（2.8％比0％）发生率均明显降低（ P均＜0.05），术后12个月，与常规治疗组比较，联合治疗组的心绞痛（16.7％比6.0％）、亚急性血栓（11.1％比0％）、心肌梗死（8.3％比0％）、心力衰竭（2.8％比0％）、再入院（11.1％比0％）发生率均明显降低（P＜0.05或＜0.01）。结论：Firebird支架联合替罗非班用于急性心肌梗死中的疗效显著，且安全可靠，值得推广。%Objective:To evaluate therapeutic effect and safety of Firebird stent combined tirofiban on acute myocar‐dial infarction (AMI) .Methods :A total of 86 AMI patients treated in our hospital from Aug 2011 to Aug 2013 were selected .According to random number table method ,patients were divided into combined treatment group (n=50 , received Firebird stenting combined tirofiban treatment ) and routine treatment group (n=36 ,received bare metal stenting) .Patients were followed up for 12~18 months ,therapeutic effects ,incidence rates of clinical events were compared between two groups .Results:After PCI ,compared with routine treatment group ,there were significant reductions in percentage of TIMI class 1~2 (13.9% vs .4.0% ) and corrected TIMI frame [ (29.2 ± 4.4) vs .(21.4 ± 5.1)] ,significant rise in percentage of TIMI class 3~4 (86.1% vs .96.0% ) in combined treatment group , P<0.05 all;on six months after PCI ,compared with routine treatment group ,there were significant reductions in inci‐dence rates of subacute thrombosis (2.8% vs .0% ) and myocardial infarction (2.8% vs . 0% ) in combined treat‐ment group (P<0.05 both);on 12 months after operation ,compared with routine treatment group ,there were sig‐nificant reductions in incidence rates of angina pectoris (16.7% vs .6.0% ) ,subacute thrombosis rate (11.1% vs . 0% ) ,myocardial infarction (8.3% vs .0% ) ,heart failure (2.8% vs .0% ) and rehospitalization rate (11.1% vs . 0% ) in combined treatment group , P<0.05 or <0.01 .Conclusion:Firebird stent combined tirofiban possesses sig‐nificant therapeutic effect on acute myocardial infarction ,and it's safe and reliable ,which is worth extending .