目的：探讨心理疏导和药物干预对冠脉旁路移植术（CABG）患者焦虑抑郁的疗效。方法：115例行CABG患者随机被分为联合干预组（60例）和常规护理组（55例），在围手术期联合干预组在常规护理基础上给予心理疏导和氟哌噻吨美利曲辛片（黛力新）和舍曲林。从社区中选择25位相匹配的正常人作为正常对照组，在手术前后评价三组Zung焦虑自评量表（SAS）和抑郁自评量表（SDS）得分，并进行比较。结果：干预前联合干预组和常规护理组之间SAS和SDS标准分差别无统计学意义（ P＞0.05），但均明显高于正常对照组（P均＜0.01）。术后联合干预组SAS和SDS标准分均明显低于术前（P均＜0.01），且明显低于常规护理组[SAS ：（41.31±6.13）分比（51.35±8.95）分，SDS ：（40.20±5.80）分比（51.22±8.78）分，P均＜0.01]。结论：心理疏导加上药物干预可明显减轻冠状动脉旁路移植术病人术后患者焦虑和抑郁情绪，有助于改善术后预后。%Objective:To explore the therapeutic effect of psychological and drug intervention on anxiety and depres‐sion in patients after coronary artery bypass graft (CABG) .Methods :A total of 115 patients performed CABG were randomly divided into combined intervention group (n=60) and routine nursing group (n=55) .During peropera‐tive period ,combined intervention group received psychological intervention ,flupentixol and melitracen tablet and sertraline based on routine nursing .A total of 25 matching normal people were selected from community and regar‐ded as normal control group ,scores of Zung self‐rating anxiety scale (SAS) and self‐rating depression scale (SDS) were evaluated and compared among three groups before and after operation .Results :Before intervention ,there were no significant difference in standard scores of SAS and SDS between combined intervention group and routine nursing group ( P > 0.05) ,but they were all significantly higher than those of normal control group , P < 0.01 all . After operation ,standard scores of SAS and SDS in combined intervention group were significantly lower than be ‐ fore operation ( P < 0.01 both) ,and they were significantly lower than those of routine nursing group [SAS : (41.31 ± 6.13) scores vs .(51.35 ± 8.95) scores ,SDS : (40.20 ± 5.80) scores vs .(51.22 ± 8.78) scores , P < 0.01 both] . Conclusion :Psychological combined drug intervention could significantly relieve anxiety and depression in patients after coronary artery bypass graft ,which is helpful for improving postoperative prognosis .
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