血清胱抑素C含量与老年良性前列腺增生症患者肾功能的相关性

摘要

目的：探讨老年良性前列腺增生症（BPH）患者血清胱抑素 C（Cys C）的变化，及其与肾功能的相关性。方法：回顾性分析237例老年 BPH 患者的临床资料，按照国际前列腺症状评分（IPSS），分为轻度25例、中度67例、重度145例；纳入同期非前列腺增生患者110例作为正常对照组。检测各组血清 Cys C、血尿素氮（BUN）、肌酐（Scr）、空腹血糖（FBG）、血脂和前列腺特异性抗原（PSA）水平，计算前列腺体积（PV）。结果：与正常对照组比较，BPH 患者的 PV显著增大[（18.94±4.62）ml 比（40.09±12.72）ml]，最大尿流率（Qmax ）显著降低[（18.67±4.60）ml／s 比（9.93±3.54）ml／s]，血清 Cys C 水平显著升高[（1.03±0.23）mg／L 比（1.53±0.61）mg／L]，P 均＜0.01。亚组分析显示，在轻、中、重度 BPH 组血清 Cys C 水平[（1.32±0.45）mg／L，（1.42±0.32）mg／L，（1.61±0.64）mg／L]均显著高于正常对照组（P 均＜0.01）；且重度组显著高于轻、中度组（P ＜0.01或 P ＜0.05）。Pearson 相关分析显示，血清 Cys C与 BPH 患者的年龄、收缩压、舒张压、FBG、BUN、Scr、PV、IPSS 评分均呈显著正相关（r＝0.179～0.580，P ＜0.05或＜0.01），与 Qmax 呈显著负相关（r＝－0.243，P ＜0.05）。结论：血清 Cys C 水平在老年 BPH 患者显著升高，且与前列腺增生程度有关，与肾功能相关，可用于预测老年 BPH 患者的肾功能。%Objective:To explore the correlation between serum cystatin C (Cys C)content and renal function in aged patients with benign prostatic hyperplasia (BPH).Methods:Clinical data of 237 aged BPH patients were retro-spectively analyzed.According to international prostate symptom score (IPSS),they were divided into mild group (n=25),moderate group (n=67)and severe group (n= 145);another 110 patients without prostatic hyperplasia were enrolled as normal control group in the same period.Levels of serum Cys C,blood urea nitrogen (BUN),ser-um creatinine (Scr),fasting blood glucose (FBG),blood lipids and prostate-specific antigen (PSA)were measured in all groups,and prostate volume (PV)was calculated.Results:Compared with normal control group,PV signifi-cantly rose [(18.94±4.62)ml vs.(40.09±12.72)ml],maximum urinary flow rate (Qmax)significantly reduced [(18.67±4.60)ml/s vs.(9.93±3.54)ml/s],and serum Cys C level significantly increased [(1.03±0.23)mg/L vs.(1.53±0.61)mg/L]in BPH group,P <0.01 all.Subgroup analysis indicated that serum Cys C levels in mild, moderate and severe group [(1.32±0.45)mg/L,(1.42±0.32)mg/L,(1.61 ±0.64)mg/L]were significantly higher than that of normal control group,P <0.01 all;and that of severe group was significantly higher than those of mild group and moderate group (P <0.01 or P <0.05).Pearson correlation analysis indicated that serum Cys C level was positively correlated with of age,SBP,DBP,FBG,BUN,Scr,PV and IPSS (r=0.179~0.580,P <0.05 or P <0.01),and inversely correlated with Qmax (r=-0.243,P <0.05)in BPH patients.Conclusion:Serum Cys C level significantly rise,and related with BPH degree,correlated with renal function in aged BPH patients,which can be used to predict renal function of these patients.