冠心病患者血浆氧化低密度脂蛋白与血管内皮损伤程度的相关性

摘要

Objective: To explore correlation between plasma oxidized low density lipoprotein (ox-LDL) and endothelial injury degree in patients with coronary heart disease (CHD).Methods: A total of 80 CHD patients were enrolled as CHD group, and 21 healthy subjects were selected as healthy control group.Plasma ox-LDL, circulatory endothelial cell count (CEC), nitric oxide (NO) levels were measured and compared between two groups, and their correlation was analyzed.Results: Compared with healthy control group, there were significant rise in plasma ox-LDL level[(350±173) μg/L vs.(687±169) μg/L]and CEC[(2.5±0.5) ×106个/L vs.(9.0±1.7) ×106个/L], and significant reduction in NO level[(77.4±21.1) μmol/L vs.(52.3±16.6) μmol/L]in CHD group, P<0.05 or <0.01.Spearman correlation analysis indicated that ox-LDL was significant positively correlated with CEC (r=0.793, P=0.019), and ox-LDL, CEC were significant negatively correlated with NO level (r=-0.782,-0.952, P=0.013, 0.021).Conclusion:There are significant positively correlation between ox-LDL and circulatory endothelial cell count(Vascular endothelial injury degree) in CHD patients, therefore, its treatment should focus on anti-inflammatory and endothelial cell function protection.%目的:探讨冠心病患者血浆氧化低密度脂蛋白(ox-LDL)与内皮损伤程度的相关性.方法:选择80例冠心病患者(CHD组),21例正常人群(健康对照组),检测各组血浆ox-LDL、循环内皮细胞计数(CEC)、一氧化氮(NO)水平,并分析其相关性.结果:与健康对照组比较,CHD组患者ox-LDL水平[(350±173) μg/L比(687±169) μg/L]、CEC[(2.5±0.5) ×106个/L比(9.0±1.7) ×106个/L]明显增加,NO[(77.4±21.1) μmol/L比(52.3±16.6) μmol/L]水平明显降低(P<0.05或<0.01).Spearman相关分析显示,ox-LDL与CEC呈明显正相关(r=0.793,P=0.019), ox-LDL, CEC与NO呈明显负相关(r=-0.782,-0.952,P=0.013, 0.021).结论:冠心病患者血浆氧化低密度脂蛋白与循环内皮细胞计数(血管内皮损伤程度) 呈明显正相关,因此对于冠心病患者应重视抗炎和保护血管内皮细胞.