循环微粒参与动脉粥样硬化进程的机制

摘要

微粒是直径0.1~1.0μm的囊泡样结构.它是细胞在活化或凋亡后产生的,具有生理性和病理性的双重作用.循环微粒的水平在多种心血管疾病中是升高的.它在血浆中的升高被认为是血管功能改变的一个生物学标志.本篇综述旨在总结和提供循环微粒在动脉粥样硬化性炎症中扮演的角色的最新研究进展.%Microparticles are vesicle-like structures with a diameter of 0.1 to 1.0 μm.It′s produced after cell activa-tion or apoptosis,which possesses physiological and pathological effects.Microparticle level rises in many cardiovas-cular diseases.Its elevation in plasma is thought to be a biomarker of vascular function change.The present article aimed at summarizing and providing newest research progress for microparticles playing role in atherosclerotic in-flammation.