氨氯地平联合美托洛尔对高血压患者的疗效及对血压、心率的影响

摘要

目的:探讨氨氯地平联合美托洛尔对原发性高血压患者血压、心率的影响及其疗效.方法:选择我院收治的原发性高血压患者160例,分为单纯氨氯地平治疗组(氨氯地平组,80例)和氨氯地平联合美托洛尔治疗组(联合治疗组,80例),4周为一疗程,对两组患者的血压、心率、临床疗效、不良反应进行统计分析.结果:与治疗前比较,治疗后两组血压均有明显下降(P均=0.001);与氨氯地平组比较,联合治疗组治疗后心率[(74.5 ± 7.8)次/min比(70.3 ± 5.2)次/min]明显下降,总有效率明显提高(82.5% 比95.0%),不良反应发生率显著降低(35.0% 比12.5%),P<0.05或<0.01.两组治疗后血压无显著差异(P均>0.05).结论:氨氯地平联合美托洛尔较单纯氨氯地平能更显著降低原发性高血压患者的心率,提高疗效.%Objective:To explore therapeutic effect of amlodipine combined metoprolol and its influence on blood pressure and heart rate in patients with essential hypertension(EH).Methods:A total of 160 EH patients treated in our hospital were selected,randomly and equally divided into pure amlodipine treatment group(amlodipine group)and amlodipine combined metoprolol group(combined treatment group),and four weeks were treated as a treat-ment course.Blood pressure,heart rate,clinical therapeutic effect and incidence of adverse reactions were statisti-cally analyzed in two groups.Results:Compared with before treatment,there were significant reductions in blood pressure in two groups after treatment,P=0.001 all;compared with amlodipine group after treatment,there were significant reductions in heart rate[(74.5 ± 7.8)beats/min vs.(70.3 ± 5.2)beats/min]and incidence rate of ad-verse reactions(35.0% vs.12.5%),and significant rise in total effective rate(82.5% vs.95.0%)in combined treatment group after treatment,P<0.05 or <0.01.There was no significant difference in blood pressure between two groups after treatment,P>0.05 all.Conclusion:Compared with pure amlodipine,amlodipine combined metoprolol can more signifi-cantly reduce heart rate and improve therapeutic effect in patients with essential hypertension.