Objective: To explore the correlation among serum levels of carbohydrate antigen 125 (CA125), uric acid (UA) and cardiac function in advanced aged patients with chronic heart failure (CHF). Methods: A total of 110 advanced aged inpatients were enrolled. According to NYHA cardiac function classification, they were divided into heart failure (HF) group (n=65, including 30 cases of class II and 35 cases of class III～IV) and normal cardiac function group (n=45). Levels of CA125, CA199, carcino-embryonic antigen (CEA), UA and N terminal pro brain natriuretic peptide (NT-proBNP), mitral early diastolic peak flow velocity/mitral late diastolic peak flow velocity (E/A) and left ventricular ejection fraction (LVEF) were measured and compared between two groups and between patients with difference NYHA class. Results: Compared with normal cardiac function group, there were significant rise in levels of CA125 [(15. 9±6. 3) U/ml vs. (40. 1±12. 2) U/ml], UA [(319. 2±61. 3) μmol/L vs. (435. 7±72. 9) μmol/L]and NT-proBNP [(298. 5±132. 4) pg/ml vs. (1923. 7±868. 6) pg/ml], and significant reductions in E/A [(1. 02±0. 46) vs. (0. 71±0. 25)] and LVEF [(62. 1±11. 9) ％ vs. (48. 7±14. 7) ％]in HF group, P=0. 001 all. Compared with class II group, there were significant rise in levels of CA125 [(28. 4±9. 3) U/ml vs. (50. 1±13. 9) U/ml], UA [(383. 4±71. 8) μmol/L vs. (478. 4±73. 9) μmol/L]and NT-proBNP [(853. 2±361. 5) pg/ ml vs. (2841. 3±1303. 3) pg/ml], and significant reductions in E/A [(0. 78±0. 23) vs. (0. 65±0. 19)] and LVEF [(52. 6±10. 1) ％ vs. (45. 3±13. 1) ％]in class III～IV group, P＜0. 05 or＜0. 01. Pearson linear correlation regression analysis indicated that levels of CA125, UA and NT-proBNP were significant inversely correlated with E/A and LVEF in HF group (r=-0. 679～-0. 457, P＜0. 05 or＜0. 01). Conclusion: Levels of CA125, UA and NT-proBNP are significant inversely correlated with LVEF in advanced aged CHF patients, which help to determine HF severity.%目的:探讨高龄慢性心力衰竭(CHF)患者血清糖蛋白抗原125(CA125)、尿酸(UA)水平与心功能之间的相关性. 方法:纳入110例高龄住院患者, 根据NYHA心功能分级标准分为心衰组65例(心功能Ⅱ级30例, 心功能Ⅲ～Ⅳ级35例)和心功能正常组45例. 分别检测比较两组以及不同心功能等级患者间CA125、CA199、癌胚抗原(CEA)、UA、N末端脑钠肽前体(NT-proBNP)水平、二尖瓣舒张早期峰值血流速度/二尖瓣舒张晚期峰值血流速度(E/A)和左室射血分数(LVEF). 结果:与心功能正常组比较, 心衰组CA125[(15. 9±6. 3)U/ml比(40. 1±12. 2)U/ml]、UA[(319. 2±61. 3)μmol/L比(435. 7±72. 9)μmol/L]、NT-proBNP[(298. 5±132. 4)pg/ml比(1923. 7±868. 6)pg/ml]显著升高而E/A[(1. 02±0. 46)比(0. 71±0. 25)]、LVEF[(62. 1±11. 9)％比(48. 7±14. 7)％]显著降低(P均=0. 001). 与心功能Ⅱ级组比较, 心功能Ⅲ～Ⅳ级组CA125[(28. 4±9. 3)U/ml比(50. 1±13. 9)U/ml]、UA[(383. 4±71. 8)μmol/L比(478. 4±73. 9)μmol/L]、NT-proBNP[(853. 2±361. 5)pg/ml比(2841. 3±1303. 3)pg/ml]水平显著升高而E/A[(0. 78±0. 23)比(0. 65±0. 19)]、LVEF[(52. 6±10. 1)％比(45. 3±13. 1)％]显著降低(P＜0. 05或＜0. 01). Pearson直线相关回归分析示:心衰组CA125、UA、NT-proBNP水平与E/A及LVEF均呈显著负相关(r=-0. 679～-0. 457, P＜0. 05或＜0. 01). 结论:CA125、UA和NT-proBNP水平与高龄CHF患者LVEF均呈显著负相关, 有助于心衰严重程度的判断.
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