冠心病患者腹型肥胖与高敏C反应蛋白和组织基质金属蛋白酶抑制物-1的相关性分析

摘要

目的：探索冠心病患者腹型肥胖与高敏 C 反应蛋白(hs-CRP)和组织基质金属蛋白酶抑制物-1(TIMP-1)之间的关系。方法85名研究对象分为稳定型冠心病组和健康对照组,均测量身高、体质量、腰围、臀围,同时计算体质指数和腰臀比；进行双能 X 线吸收法扫描,记录全身及腰部、臀部的脂肪含量,计算全身脂肪比例、腰臀部脂肪比。于空腹状态进行血脂指标及 hs-CRP、TIMP-1检测。分析两组间 hs-CRP 和 TIMP-1差异,hs-CRP 和 TIMP-1与体脂、血脂的相关性。结果冠心病组hs-CRP[(3.41±3.73) mg/ L]高于健康对照组[(1.48±1.28) mg/ L]( P <0.01),TIMP-1值比较[(46.32±17.86) mg/ L 比(51.39±16.50)mg/ L]差异无统计学意义(P =0.21)。冠心病组及健康对照组 hs-CRP 与 WC、BMI、WHR、A/ G 均有正相关性(均为 P <0.05),两组 TIMP-1与体脂测量指标、血脂指标、hs-CRP 均无相关性(均为 P >0.05)。结论 hs-CRP 随着体脂含量及腹内脂肪含量增加而增加,提示肥胖是一种慢性低度炎症反应状态,而 TIMP-1与腹内脂肪含量增加没有相关性。%Objective To investigate the relationship between intra-abdominal obesity and the serum levels of inflammatory factors- high sensitive C-reactive protein ( hs-CRP) and tissue inhibitor of metalloproteinase-1(TIMP-1) in patients with coronary heart disease ( CHD) . Methods A total of 85 persons were divided into two groups, CHD group and control group. The height, body weight, waist circumference (WC), body mass index ( BMI) and waist-to-hip ratio( WHR) were recorded and blood fasting total cholesterol ( TC), triglyceride ( TG), high density lipoprotein cholesterol ( HDL-C), low density lipoprotein cholesterol (LDL-C), high sensitive C-reactive protein (hs-CRP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured for all subjects. All subjects were evaluated with a DEXA total body scan performed using a Lunar Prodigy system ( GE Healthcare) . The body fat composition and distribution,serum levels of inflammatory factors were also analyzed. Results The level of hs-CRP was significantly higher in CHD group than in control group [(3. 41 ± 3. 73) mg/ L vs. (1. 48 ± 1. 28) mg/ L, P < 0. 01]. The level of TIMP-1 had no significant deviation between the two groups [(46. 32 ±17. 86) mg/ L vs. (51. 39 ± 16. 50)mg/ L, P = 0. 21]. In both groups, hs-CRP had positive correlation with WC,BMI, WHR and A/ G(all P < 0. 05), the level of TIMP-1 was not significantly correlated with BMI, WC, WHR, TF% , A/ G, LDL-C and hs-CRP(all P > 0. 05). Conclusions The accumulation of abdominal adipose tissue is closely correlated to higher hs-CRP. An extent of chronic inflammatory stress might exist in obese person. The level of hs-CRP is significantly increased in CHD patients. However,there is no significantly correlation between serum TIMP-1 and the accumulation of abdominal adipose tissue.