心力衰竭患者心脏再同步化治疗后近期及远期随访研究

摘要

目的：连续随访行心脏再同步化治疗( CRT）的心力衰竭患者，观察近期、远期患者心功能改善情况。方法连续入选在我院心血管内科住院的终末期心力衰竭患者45例，分别评估和(或）测量患者术前、术后半年、1、2年的 NYHA 分级、左室舒张末内径( LVED ）、左室射血分数(LVEF）及血浆脑钠肽(BNP）浓度。结果与术前相比，术后半年、1、2年患者 NYHA 分级改善、LVED缩小、LVEF 增大、血浆 BNP 浓度下降(均为 p <0.05）；与术后半年相比，术后1、2年患者NYHA分级改善、LVED缩小、LVEF增大、血浆BNP浓度下降(均为p<0.05）；与术后1年相比，术后2年NYHA分级没有改善、LVED无变化、LVEF无增大、血浆BNP浓度无下降(均为p》0.05）。结论CRT能够改善心力衰竭患者术后半年、1年心脏功能，但术后2年随访心脏功能无进一步改善。%Objective To assess short-term and long-term effects of cardiac resynchronization therapy ( CRT) in heart failure patients. Methods We continuously assessed forty-five end-stage heart failure patients. NYHA grade,left ventricular diastolic diameter (LVED), left ventricular ejection fraction ( LVEF) and B-type natriuretic peptides ( BNP) before cardiac resynchronization therapy and at six months, one year, two years after cardiac resynchronization therapy were evaluated. Results Compared to the results before cardiac resynchronization, six months, one year and two years after CRT, NYHA grade, LVEF, LVED,BNP improved significantly (all p<0. 05). Compared to the results of six months after CRT, one year and two years later, NYHA grade, LVEF, LVED,BNP also improved significantly (all p<0. 05). The results of one year and two years after CRT, including NYHA grade, LVEF, LVED and BNP, were similar (all p》0. 05). Conclusions CRT could improve the short-term and long-term myocardial function of hear failure patients.