视黄醇结合蛋白4与心血管疾病关系的研究进展

摘要

Retinol binding protein 4(RBP4)is a kind of lipophilic carrier protein ,and also a kind of small hydrophobic molecules-binding protein.Its function is transferring all kinds of active metabolite (retinol)from Vitamin A. Thus help the Vitamin A to play its chief physiological function. Many Clinical researches show that the RBP4 is related to many risk factors of cardiovascular disease such as the arteriosclerosis ,Insulin resistance ,disorders of lipid metabolism and obesity and is also some correlated to the cardiovascular disease including Hypertension and heart failure.So this article will summarize the structure and function of RBP4 and its related research in the field of cardiovascular disease.%视黄醇结合蛋白（RBP4）是一种亲脂载体蛋白，也是一种疏水小分子结合蛋白，在体内负责结合并转运维生素 A 的各种活性代谢物（视黄醇类），从而协助维生素 A 发挥其主要生理功能。临床多项研究显示 RBP4与动脉硬化、胰岛素抵抗、脂质代谢紊乱、肥胖等心血管危险因素密切相关，并且与心血管疾病如冠心病、高血压和心力衰竭的病理生理有一定相关性。本文将对 RBP4的结构功能及其在心血管疾病中的相关研究进展做一综述。