严重烧伤病人早期血浆内皮素变化与心肌损害关系的初步探讨

摘要

Objective: To study the effect of plasma endothelin (ET) level on myocardial injury of severely burned patients. Method: Plasma ET level was determined by radio－ immunoassay and plasma levels of CK-MB by automatic serum biochemical assay. Result: Plasma ET level increased significantly 12 hr post burn as compared with normal persons (P<0.01), plasma CK MB increased significantly within first 24 hr post burn. Plasma ET level was positive correlated to CK MB level. Conclusion: The results suggested that elevated plasma ET level may be involved in the damage of myocardium in the early stage of severe burn.%目的：探讨血浆内皮素(ET)变化与烧伤早期心肌损害的关系。方法：采用放免法检测5例严重烧伤病人烧伤早期血浆ET和ASCA仪测定血浆肌酸激酶同工酶(CK－MB)。结果：伤后12h血浆ET（106.0±1.6pg/ml，n=5）较正常人组（47.6±3.4pg/ml，n=8）明显升高。血浆CK－MB在伤后明显升高。相关分析显示，ET升高与CK－MB呈高度正相关。结论：血浆ET升高可能参与了烧伤早期的心肌损害。