基于可穿戴式传感装置的帕金森运动症状量化评估的研究进展

摘要

帕金森病(PD)运动症状的量化评估是PD诊疗中的一个难题;基于MEMS(微机电系统)运动传感器的可穿戴式装置可以跟踪PD病人设定动作和自主运动等运动信息,从而实现帕金森运动症状的实时和客观的量化评估.首先介绍MEMS运动传感器技术及用于帕金森运动症状量化评估的典型性可穿戴式系统,包括其局限性;然后对震颤/异动症、缓慢运动、肌肉僵直、姿势步态障碍等4个主要运动症状的量化评估方法及其与神经科医生临床判断相关性分别进行对比和分析;同时对PD症状波动等运动并发症对运动症状量化评估的影响进行讨论.介绍MEMS运动传感技术在PD运动症状量化评估中的应用及其精确性,为基于可穿戴式传感装置的帕金森运动症状定量评估研究提供一个基础框架.%The quantitative assessment of motor symptoms of Parkinson's disease (PD) has remained a significant challenge since PD was first defined in 1817.However,with benefits of MEMS (Micro-Electro-Mechanical Systems) motion sensors for high-precision motion tracking,together with the multivariate statistical analysis and estimation theory,PD motor symptoms quantification has become available.In this article,at first,the MEMS motion sensing technique and the typical wearable systems for the quantification of PD motor symptoms were introduced.Secondly,the quantification methods of the four primary motor symptoms and their correlations to the UPDRS judgments of neurologists were compared and analyzed.After that,the impacts of motor fluctuations and the side effects of treatments such as dyskinesia for the quantification of PD symptoms were discussed.This paper also introduced the recent advances in quantitative assessment of parkinsonian motor symptoms based on wearable devices,and provides a system structure for the research of quantitative assessment of PD motor symptoms.