各地区人类嗜T细胞病毒Ⅰ型的聚类分析

摘要

已有相关文献表明人类嗜T细胞病毒Ⅰ型(Human T-lymphotropic virus 1,记为HTLV-Ⅰ)的分布具有区域性,本文旨在提出不同的分析区域性的方法.首先从GenBank中选取来自亚洲、南美洲、非洲的共20条核苷酸序列,用分子生物学软件Vector NTI Suite分析各地区序列样本内部的同源性,然后以各序列的氨基酸含量为对象,定义一个全新的公式进行同源性分析,将该结果与其他研究者采用实验的方法的分析结果比较.结果发现不同的分析方法所得的结论均是一致的.这表明:HTLV-Ⅰ病毒的分布有明显的区域性,文章采用的研究方法对其他流行病学的研究是同样可行的.%Objective: Some related literatures indicated that the distribution of Human T - lymphotropic virus 1 ( HTLV — Ⅰ ) was regional. This passage was to research the area characteristic of this virus further. Method; Firstly, 20 sequences of nucleotide which come from Asia 、 South America 、Africa were chosen in GenBank, molecular biology software Vector NTI Suite was used to analysis the homology of the samples in each area, then a new formula based on the purity of amino acid was defined to analysis homology. Resu In all samples, China and Japan belonged to one class, South America and Africa belonged to another, this was as same as the result of some related passages. Conclusion; The area characteristic of HTLV - Ⅰ was evident. The research method of this passage was also feasible to the other epidemic diseases.