miR-21的高表达与胰腺癌预后关系的meta分析

摘要

To evaluate the correlation between the overexpression of miR-21 and the prognosis of pancreatic cancer , we search of PubMed, EMBASE, Google, scholar, VIP, CNKI database, which has been published on the overexpression of miR-21 and prognosis of pancreatic cancer related literature , the quality of the original documents evaluation according to the requirements of meta analysis , statistical analysis is performed using STATA V 12.0 software to study the effect of the amount of .Results show a total of 4 articles (300 cases) are included, and the overall survival rate (OS) HR is 1.26 (95%CI:1.08-1.47, P<0.05).We draw conclusions that a risk factor for the prognosis of pancreatic cancer is high expression of miR-21.%为评价miR-21的高表达与胰腺癌预后的相关性，通过全面检索PubMed， EMBASE， Google scholar，维普，CNKI等数据库，收集已公开发表的关于miR-21的高表达与胰腺癌预后相关性的文献，按meta分析的要求对原始文献的质量进行评估，采用STATA V12．0软件对各研究的效应量进行统计分析。结果发现共纳入4篇文献（共300个病例），合并总生存率（OS）HR为1．26（95％CI：1．08～1．47，P＜0．05）。由此可以推断胰腺癌预后的一个危险因素为miR-21的高表达。