目的：探讨参一胶囊联合多西紫杉醇＋顺铂治疗晚期乳腺癌患者的临床疗效及对患者生活质量的影响。方法选择黄石市中心医院普爱院区肿瘤外科2013年7月～2014年12月收治的135例患者，随机将其分为治疗组（ n＝69）和对照组（ n＝66）。2组均进行常规基础治疗，对照组采用多西紫杉醇（75 mg／m2，2次／天）＋顺铂（25 mg／m2，1次／天）治疗，治疗组在对照组的基础上联合参一胶囊（20 mg，2次／天）治疗，4周为1个疗程，连续治疗12周。观察比较2组临床疗效及生活质量情况。结果治疗组的缓解率为63.77％，明显高于对照组的40.91％，2组比较差异有统计学意义（χ2＝7.070，P＝0.008）。治疗后，治疗组SF-36评分显著升高（63.87±12.08 vs 54.69±8.78）（P＜0.05），且明显高于对照组（57.95±11.95）分（P＜0.05）。治疗后，治疗组患者不良反应发生情况显著低于对照组，2组比较差异存在统计学意义（Z＝2.858，P＝0.004）。结论参一胶囊联合多西紫杉醇＋顺铂治疗晚期乳腺癌的临床效果显著，可以明显改善患者临床疗效及生活质量情况。%Objective To explore clinical effect and life quality study of Shenyi capsule combined with docetaxel and cisplatin in treatment of advanced breast cancer.Methods 135 cases of advanced breast cancer of Huangshi Central Hospital were collected and diagnosed from July 2013 to December 2014 in accordance with the random number table,were divided into treatment group(n=69) and control group(n=66).Both groups were given regular basis treatment, control group was treated by docetaxel(75 mg/m2,twice a day)and cisplatin(25 mg/m2,once a day), and treatment group combined with Shenyi capsule(20 mg,twice a day)on the basis of control group treatment.4 weeks were 1 course, and all the cases were taken 12 weeks of continuous treatment.Observed and compared the clinical efficiency and life quality of two groups.Results The remission rate of 63.77% in treatment group was higher than control group of 40.91%, difference was statistically significant(χ2 =7.070,P=0.008).After treatment, the SF-36 scale in treatment group significantly increased from ( 54.69 ±8.78 ) to ( 63.87 ±12.08 ) , and higher than that of control group ( 57.95 ±11.95 ) , differences were statistically significant(P<0.05).The adverse reactions in treatment group was lower than control group, difference was statistically significant(Z=2.858,P =0.000).Conclusion The clinical effect in treatment of advanced breast canceris obvious by Shenyi capsule combined docetaxel and cisplatin.It can significantly improve clinical effect and life quality.
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