丹红注射液联合依达拉奉治疗特发性肺纤维化患者的临床疗效及对血清TNF-α和TGF-β1水平的影响

摘要

目的 探讨丹红注射液联合依达拉奉治疗特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)的临床疗效及对患者血清肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)和转化生长因子-β1(transforming growth factor-β1,TGF-β1)水平的影响.方法 选择南京市玄武医院于2011年3月~2014年12月收治的67例IPF患者,采用随机数字表法分为治疗组(n=35)和对照组(n=32).2组均进行常规基础治疗,对照组采用依达拉奉治疗,治疗组在对照组的基础上再给予静滴丹红注射液.治疗结束后,比较2组患者的临床有效率、动脉血氧分压(partial pressure of oxygen, PaO2)、一氧化碳弥散量(diffusing capacity, Dlco)和血清肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)以及转化生长因子-β1(transforming growth factor-β1,TGF-β1)水平的变化.结果 观察组总有效率97.14%,明显高于对照组的75.00%(Z=-2.035,P=0.042).治疗后,观察组PaO2 和一氧化碳的弥散量(Dlco)较治疗前明显升高(P<0.05),且显著高于对照组(P<0.05).治疗后,观察组TNF-α和TGF-β1的水平显著降低(P<0.05);与对照组相比明显更低(P<0.05).结论 丹红注射液联合依达拉奉治疗IPF的临床疗效显著,可以明显改善IPF患者的肺功能和炎性因子水平.%Objective To investigate clinical effect of Danhong injection combined with edaravone in patients with idiopathic pulmonary fibrosis (IPF) and influence on TNF-αand TGF-β1 in serum.Methods 67 patients were randomly divided into Treatment Group (n=35) and Control Group (n=32) in Xuanwu hospital of Nanjing from March 2011 to December 2014.All the patients were treated by comprehensive conventional treatment, and then control group was treated by edaravone, treatment group were treated by Danhong injection on the basis of control group.The clinical efficiency, PaO2 , carbon monoxide diffusing capacity (Dlco) and the levels of inflammatory factors between two groups were compared.Results After treatment, the clinical total effective rate(97.14%) of treatment group was statistically higher than that of control group (75.00%, Z=-2.035,P=0.042).After treatment, partial pressure of oxygen(PaO2) and Dlco in treatment group were increased significantly(all P<0.05);and it was statistically higher then control group (all P<0.05).TNF-αand TGF-β1 in treatment group were decreased significantly (all P<0.05);and it was also statistically higher then control group (all P<0.05).Conclusion Danhong injection combined with edaravone is effective in treatment of IPF, which can significantly improve the pulmonary function and levels of inflammatory factors.