参芪扶正注射液对腹腔镜结肠癌根治术患者术后血清CA19-9、CRP、CD4+淋巴细胞亚群影响研究

摘要

目的 探讨参芪扶正注射液对腹腔镜结肠癌根治术患者术后血清糖链抗原19-9(carbohydrate antigen 19-9,CA19-9)、C反应蛋白(C-reaction protein,CRP)、CD4 +淋巴细胞亚群的影响.方法 收集收治的进行腹腔镜结肠癌根治术的患者58例,根据用药不同分为对照组和实验组,每组各29例,术后分别给予相应的药物治疗,治疗结束后,对所有患者的血清CA19-9、CRP及静脉血T淋巴细胞水平进行检测.结果 与治疗前比较,2组患者血清CA19-9、CRP水平降低(P<0.05) ,静脉血CD4 +细胞、CD4+/CD8 +以及NK细胞水平升高(P<0.05).治疗后与对照组比较,实验组患者血清CA19-9、CRP水平较低(P<0.05);实验组患者的静脉血CD4 +细胞、CD4 +/CD8 +以及NK细胞水平较高(P<0.05).结论 参芪扶正注射液能够显著降低腹腔镜结肠癌根治术患者术后血清CA19-9、CRP水平,提高静脉血CD4+细胞、CD4 +/CD8 +以及NK细胞水平,改善免疫功能,对临床有指导意义.%Objective To analyse effect of ShenQi FuZheng injection on serum carbohydrate antigen 19-9(CA19-9), C-reaction protein(CRP) and CD4 +lymphocyte subsets in patients after laparoscopic radical resection of colon cancer.Methods 58 patients after laparoscopic radical resection of colon cancer were collected.All patients were randomly divided into experimental group and control group according to the different drugs, 29 cases in each group.Patients were given the corresponding drug treatment after operation, after the treatment, the serum levels of CA19-9, CRP and venous blood T lymphocyte level were detected in all patients.Results Compared with before treatment, CA19-9 and CRP level in serum were lower (P<0.05) , CD4 +cells, CD4 +/CD8 +, and NK cells were higher(P<0.05);Compared with control group after treatment, the serum CA19-9 and CRP level were lower in the experimental group (P<0.05); the levels of venousblood CD4 +cells, CD4 +/CD8 +and NK cells were higher in the experimental group (P<0.05).Conclusion ShenQi FuZheng injection can significantly reduce the serum CRP and CA19-9 levels in patients after laparoscopic radical resection of colon cancer, improve the levels of venous blood CD4 +cells, CD4 +/CD8 +and NK cells, improve immune function, and have a guiding significance for clinica.