环氧树脂类糊剂与生物陶瓷类糊剂对白细胞介素－1、白细胞介素－6、白介素－10、超敏C反应蛋白影响的对比研究

摘要

Objective To explore effect of the paste epoxy resins and biological ceramic paste on interleukin 1 ( IL-1 ) , interleukin 6 ( IL-6 ) , interleukin 10 (IL-10), hypersensitive c-reactive protein (hs-CRP) .Methods From April 2013 to June 2015 I branch 120 cases were randomly selected as the research object.Random grouping method divided into observation group and control group, 60 cases of control group and 60 cases of observation group.In observation group was given with epoxy resin paste for root canal filling, control group was given with biological ceramic paste for root canal filling, compared two groups of IL -1, IL-6 and IL-10, hs-CRP.ResuIts after treatment in two groups IL-1,IL-6, hs-CRP content decreased significantly, and the observation group had a significantly higher degree of decline in the control group.Two groups of IL-10 level significantly increased, higher degree was significantly higher than the control group and observation group, which were statistically significant differences ( all P3 d accounted for 20.00%was lower than the control group 41.67% significantly, which were statistically significant differences (all P<0.05).Observation group’ s curative effect for instituting accounted for 98.33%, were significantly higher than that of control group 88.33%, which were statistically significant differences ( P<0.05 ) .Observation group of PD, GI, GCF level was significantly higher than the control group, which were statistically significant differences (all P<0.05).ConcIusion Epoxy resin paste such as root canal filling material, can significantly improve patients with IL-10, IL-6, hs-CRP levels, relieve patients’ pain, clinical effect is remarkable.%目的：研究环氧树脂类糊剂与生物陶瓷类糊剂对白细胞介素－1（IL－1）、白细胞介素－6（IL－6）、白介素－10（IL－10）、超敏C反应蛋白（ hs－CRP）影响和意义。方法从2013年4月～2015年6月收治的牙周炎患者中随机选取120例作为研究对象。随机分组法分为观察组60例，对照组60例。对观察组实施环氧树脂类糊剂进行根管填充，对照组实施生物陶瓷类糊剂进行根管填充，观察对比2组IL－1、IL－－6、IL－10、超敏C反应蛋白情况。结果治疗后2组IL－1、IL－6、hs－CRP含量显著降低，且观察组下降程度显著高于对照组（均P＜0．05）；2组IL－10水平显著升高，且观察组升高程度显著高于对照组（均P＜0．05）。观察组患者疼痛时间＜1 d占比35．00％，显著高于对照组的11．67％，且＞3 d的占比20．00％，显著低于对照组的41．67％，差异均有统计学意义（均P＜0．05）。观察组疗效为优良率98．33％，显著高于对照组的88．33％，差异有统计学意义（ P＜0．05）。观察组的PD、GI 、GCF水平显著高于对照组，差异均有统计学意义（均P＜0．05）。结论环氧树脂类糊剂作为根管填充材料，能显著改善患者IL－10、IL－6、hs－CRP等水平，缓解患者疼痛，临床效果显著。