利伐沙班对下肢静脉血栓患者HIF－α、P－选择素及TNF－α的影响研究

摘要

Objective To investigate the effect of rivaroxaban on HIF-α, P-selectin and TNF-αin patients with lower extremity venous thrombosis.Methods 41 cases from May 2014 to February 2015 were selected and randomly divided into two groups, 21 cases in the control group were treated by routine treatment, 20 cases in the experiment group were treated on the base of the control group with ivaroxaban.Serum HIF-α, P-selectin and TNF-αwere detected before and after the treatment.ResuIts Compared with the control group, the clinical effect were higher ( P0.05).HIF-α, P-selectin and TNF-αwere lower(P<0.05),HIF-αwas positively correlated with TNF-α(r =-0.468,P<0.05), and was not correlated with P-selectin, P-selectin was not associated with TNF-α.ConcIusion Rivaroxaban can effectively improve the lower limb venous thrombosis in patients with clinical symptoms, reduce serum HIF-α, P-selectin and TNF-αexpression, has better clinical curative effect, for clinical treatment of lower limb venous thrombosis has important significance.%目的：探讨利伐沙班对下肢静脉血栓患者血清HIF－α、P－选择素及TNF－α的影响及其意义。方法选取2014年5月～2015年2月已确诊为下肢静脉血栓的患者41例，根据随机数字表法随机分为2组：对照组21例，行临床常规疗法治疗；实验组20例，在与对照组相同的临床常规治疗基础上加用利伐沙班片，检测2组患者的临床症状、不良反应发生率、血清HIF－α、P－选择素及TNF－α水平及其相关性，进而对2种治疗方法的临床疗效进行对比分析。结果实验组患者经治疗后临床疗效更优于对照组，与对照组比较，实验组总有效率较高（ P＜0．05），不良反应发生率比较差异无统计学意义。 HIF－α、P－选择素及 TNF－α水平较低（P＜0．05），HIF－α与P－选择素无相关性，与TNF－α呈负相关（r＝－0．468，P＜0．05），P－选择素与TNF－α无相关性。结论利伐沙班能有效改善下肢静脉血栓患者临床症状，降低血清HIF－α、P－选择素及TNF－α表达水平，有较好的临床疗效，对临床治疗下肢静脉血栓具有重要意义。