复方丹参注射液联合头孢哌酮舒巴坦钠对老年慢性肾盂肾炎患者肾功能及肾间质纤维化的影响

摘要

Objective To study the influence of Compound Salvia injection combined with cefoperazone sulbactam sodium on renal function and renal interstitial fibrosis in elderly patients with chronic pyelonephritis (CPN).Methods From April 2013 to July 2014, 126 cases of CPN were divided into observation group ( n =63 ) and control group ( n =63 ) according to the order of admission to hospital.All patients were given cefoperazone sulbactam sodium, and patients in observation group were added Compound Salvia injection.The clinical efficacy of treatment were evaluated between two groups, renal function and TGF-β1 were observed and compared before and after treatment in two groups.Results After treatment, HE staining of nephridial tissue showed renal interstitial fibrosis in observation group obvious improved more.The overall response rate of observation patients (90.48%) was significantly higher (74.60%) than control group, and the relapse rate of observation group (1.59%) was significantly lower than control group (14.29%), and there were statistically significant differences (P<0.05).After treatment, urinary albumin (11.4 ±3.1) mg/L, BUN (5.7 ±0.5) mmol/L, and Scr (103.2 ±10.4)μmol/L of observation group were significantly lower than control group, respectively (P<0.05).After treatment, TGF-β1 level (103.4 ±32.5) ng/L of observation group was significantly lower than control group (202.4 ±35.2) ng/L(P<0.05).There was no significant difference in adverse reactions between two groups.Conclusions Compound Salvia injection combined with cefoperazone sulbactam sodium has good efficacy.can significantly improve renal function, delay renal interstitial fibrosis in treatment of elderly patients with chronic pyelonephritis.%目的：研究复方丹参注射液联合头孢哌酮舒巴坦钠对老年慢性肾盂肾炎（ chronic pyelonephritis，CPN）患者肾功能及肾间质纤维化的影响。方法选择2013年4月～2014年7月河北医科大学第一医院收治的126例CPN患者，按照入院顺序将患者分为观察组（n＝63）和对照组（n＝63）。所有患者均给予头孢哌酮舒巴坦钠，观察组患者在此基础上加用复方丹参注射液。评价2组患临床疗效，观察患者治疗前后的肾功能指标，以及血清转化生长因子－β1（transforming growth factor－β1，TGF－β1）。结果治疗后肾活检HE染色结果显示，观察组患者的肾间质纤维化减轻更为明显。观察组患者总有效率（90．48％）高于对照组（74．60％），且观察组患者复发率（1．59％）低于对照组（14．29％），差异均具有统计学意义（P＜0．05）。治疗后，观察组患者的尿微量白蛋白（11．4±3．1） mg／L、BUN（5．7±0．5） mmol／L、Scr（103．2±10．4）μmol／L，均显著低于对照组（P＜0．05）。治疗后，观察组患者的TGF－β1水平（103．4±32．5） ng／L，显著低于对照组的（202．4±35．2） ng／L（P＜0．05）。结论复方丹参注射液联合头孢哌酮舒巴坦钠治疗老年慢性肾盂肾炎，疗效好，且能够明显改善肾功能，延缓肾间质纤维化。