尼美舒利对慢性牙周炎患者疗效及龈沟液中IL－8和TNF－α水平的影响

摘要

Objective To investigate the clinical efficacy of nimesulide in the treatment of chronic periodontitis patients,and analyze the effect of IL-8 and TNF-αlevels in the gingival sulcus fluid.Methods 88 patients with chronic periodontitis in our hospital between June 2014 to December 2015 were divided into control group and observation group by the random number method, 44 cases in each group, the control group patients were given metronidazole treatment, observation group patients were given nimesulide treatment,two groups therapeutic effect and the incidence of adverse reactions were observed, compared two groups of patients before and after treatment in gingival sulcus fluid IL-8 and TNF-αlevel, compared sulcus bleeding index (SBI), plaque index (PLI) and clinical attachment level (CAL),before and after treatment two weeks and four weeks of probing depth (PD) of two groups.Results The total effective rate of observation group patients was 95.55%, significantly higher than the control group patients’total efficiency (81.82%) (χ2 =4.06, P=0.04), after treatment in the observation group gingival sulcus fluid IL-8 factor and TNF-αlevels were significantly lower than the control group (P<0.05), After 2 weeks and 4 weeks of treatment, PD, SBI and CAL indicators observation group were significantly lower than the control group ( P <0.05 ) , the incidence of adverse reactions of observation group patients was 4.55%, significantly lower than the incidence of adverse reactions in control group patients(22.73%)(χ2 =6.18, P=0.01).Conclusion Nimesulide in the treatment of chronic periodontitis with a highly efficient clinical efficacy, while reducing gastrointestinal side effects, etc., can effectively reduce the gingival sulcus fluid IL-8 and TNF-αlevels, ease clinical symptoms, is a highly effective treatment.%目的：研究尼美舒利治疗慢性牙周炎患者的临床疗效，同时观察对患者龈沟液中IL－8和TNF－α水平的影响。方法选取2014年6月～2015年12月接受治疗的慢性牙周炎患者88例，按照随机数字法将其分为对照组和观察组，每组各44例，对照组患者接受甲硝唑治疗，观察组患者接受尼美舒利治疗，治疗结束后观察2组患者的治疗疗效和不良反应发生率，比较2组患者治疗前后龈沟液中IL－8和TNF－α水平，同时与治疗前、治疗后2周及4周对2组患者的探诊深度（ PD ）、龈沟出血指数（ SBI ）、菌斑指数（PLI）及临床附着水平（CAL）。结果观察组患者治疗后总有效率为95．55％明显高于对照组患者治疗后总有效率（81．82％）（χ2＝4．06，P＝0．04），治疗后观察组患者龈沟液中IL－8和TNF－α水平明显低于对照组（P＜0．05），治疗2周和4周后观察组患者的PD、SBI及CAL各项指标均明显低于对照组（P＜0．05），观察组患者的不良反应发生率为4．55％明显低于对照组患者的不良反应发生率22．73％（χ2＝6．18，P＝0．01）。结论尼美舒利可以高效治疗慢性牙周炎，同时能够减少胃肠道等不良反应发生，能有效降低龈沟液中IL－8和TNF－α水平，缓解各项临床症状，是一种高效的治疗药物。