VEGF和CYP1A1在非小细胞肺癌组织中的表达与临床意义

摘要

目的 探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)和细胞色素P4501A1(cytochrome P4501A1,CYP1A1)与肺癌的发生、发展的关系.方法 采用MaxVision免疫组化的方法检测58例肺癌组织及16例癌旁正常组织中,VEGF、CYP1A1蛋白的表达差异.结果 免疫组化结果显示:与癌旁正常组织相比,肺癌组织VEGF、CYP1A1阳性表达率均存在统计学差异(P<0.05);Ⅰ、Ⅱ期的阳性表达率与Ⅲ、Ⅳ期相比,CYP1A1、VEGF蛋白表达均存在统计学差异(P<0.05).CYP1A1、VEGF蛋白表达的相关系数r为0.723.结论 VEGF和CYP1A可能与肿瘤的发生发展有关,两个蛋白之间的表达可能存在一定关联且为正相关.%Objective To explore the relationship between VEGF and CYP1A1 and the development and progression of lung cancer. Methods 58 cases of lung cancer tissue and 16 cases of normal tissue were detected by Max vision immunohistochemistry. Results Immunohistochemistry results show: compared with adjacent normal group,there was significant difference in the positive rate ofCYP1A1 and VEGF in lung cancer group (P<0.05). The positive expression rates of CYP1A1 and VEGF were significantly different between stage I, II andIII, IV (P<0.05). The correlation coefficient of VEGF and CYP1A1 was 0.723. Conclusion VEGF and CYP1A may be associated with the occurrence and development of tumor. Correlation coefficient indicated the positive correlation between VEGF and CYP1A1expression