丹参川芎嗪注射液对急性心肌梗死PCI术后患者氧化应激和心功能的影响研究

摘要

Objective To discuss the effects of Danshen Chuanxiongqin injection on oxidative stress and cardiac function in patients with acute myocardial infarction after PCI. Methods A total of 84 patients with acute myocardial infarction underwent PCI treatment, patients were randomly divided into control group and observation group. The two groups received oral clopidogrel and aspirin before operation, and two prevention and treatment of myocardial infarction were given after operation. The treatment group was treated with Danshen Chuanxiongqin injection on the basis of the control group.The two groups were detected with superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), cardiac troponin I (TnT), creatine kinase isoenzyme (CK-MB), plasma brain natriuretic peptide (brain natriuretic, peptide, BNP) level in PCI after surgery before and after PIC 12 and PIC after 7 days.The left ventricular end diastolic diameter (LVEDD) and ejection fraction (LVEF) were compared between the two groups before and after treatment. Results Postoperative 12h, two groups of indicators were elevated. After the treatment of 7D, the treatment group MDA, TnT, CK-MB, BNP, significantly lower than the control group, SOD, NO, higher than the control group, the difference was statistically significant (P<0.05). Heart color index, LVEDD and LVEF were improved in the two groups, but there was no significant difference between the two groups. Conclusion Danshen Chuanxiongqin injection can effectively scavenge free radicals, inhibit oxidative stress, alleviate inflammation and improve ischemia-reperfusion injury and cardiac function in patients with acute myocardial infarction after PCI.%目的 探讨丹参川芎嗪对急性心肌梗死患者行经皮冠状动脉介入术后的氧化应激与心功能的影响.方法 选取急性心肌梗死84例,均行PCI术治疗,采用随机数表法将患者分为对照组和观察组各42例.2组术前均口服氯吡格雷、阿司匹林,术后给予心肌梗死二级预防治疗,治疗组在对照组基础上加用丹参川芎嗪注射液.PCI术前、PCI术后12 h,7 d检测2组患者超氧化物歧化酶(SOD),丙二醛(MDA),一氧化氮(NO),心肌钙蛋白(TnT),肌酸激酶同工酶(CK-MB)、血浆脑钠肽(brain natriuretic peptide,BNP)水平;对比治疗前后2组患者左心室舒张末内径(LVEDD),射血分数(LVEF).结果 术后12 h,2组各项指标均升高.治疗7 d后,治疗组MDA,TnT,CK-MB,BNP显著低于对照组,SOD,NO高于对照组,差异具有统计学意义(P<0.05).2组心脏彩超指数LVEDD和LVEF均改善,但组间差异无统计学意义.结论 丹参川芎嗪注射液在急性期可以可以有效清除自由基,抑制氧化应激,减轻炎症反应,改善急性心肌梗死患者PCI术后再灌注缺血损伤及心功能.