β-折叠肽自组装在生物医学方面的应用

摘要

The β-sheet peptides can be self-assembled to form different supramolecular solids. The supramolecular solid can be linked to a wide range of functional domains, for example, with cell adhesion sequences, signal domains, and vaccine epitopes to form complex nanostructures, which can be widely used in biomedical fields. In this paper, we mainly reviewed the self-assembly of peptides using β-folding secondary structure to form nanostructures, and discussed the application of nanostructures in drug delivery and tissue engineering.%β-折叠肽可以自组装形成不同的超分子固体.超分子固体可以与广泛的功能域连接,例如与细胞粘附序列、信号域、疫苗表位连接形成复杂的纳米结构,进而在生物医学领域可以得到广泛应用.本文主要综述多肽采用β-折叠二级结构自组装形成纳米结构,并讨论了纳米结构在药物递送和组织工程的应用.