正清风痛宁片联合地佐辛用于胸腔镜肺叶切除术后静脉镇痛效果及对患者血流动力学的影响分析

摘要

Objective Analyzing the effect of Zhengqingfengtongning sheet joint dezocine on the ostoperative analgesia of thoracoscopy lobectomy.Methods 79 cases of patients from February 2014 to April 2015.All patients were divided into 39 cases in the control group and the observation group of 40 patients.In the control group were treated with injections alone dezocine for postoperative analgesia, the observation group were treated with dezocine joint Zhengqingfengtongning tablets for postoperative pain treatment.After treatment, the two groups of patients with visual analog scale(VAS score), digital sedation score(NSS score), heart rate(HR), mean arterial pressure(MAP) and cardiac index(CI) and the change in adverse reactions compared analysis.Results ① After treatment, the two groups of patients were compared postoperative VAS scores showed that patients in the observation group after 6h, after 12h, 24h after the VAS scores were lower than the control group, the difference was statistically significant(P<0.05);② after treatment, the two groups of patients after NSS scores were compared, the results showed that patients in the observation group 6h, after 12h, 24h after the NSS scores were higher, the difference statistically significant(P<0.05);③ two groups of patients intraoperative HR change amount, MAP change amount, CI change the situation by comparing hemodynamic parameters in patients with fluctuations in the observation group was significantly less than the control group, the difference was statistically significant(P<0.05);④ surgery patients were not statistically significant proportion of adverse events.Conclusion On the basis of diazoxin, combined with traditional Chinese medicine, Qingfengtongning tablet can reduce the degree of venous analgesia after thoracoscopic lobectomy and stabilize the hemodynamics of patients, which is a safe and effective treatment method.Clinical promotion and use.%目的 地佐辛用于胸腔镜肺叶切除术后静脉镇痛效果及对患者血流动力学的影响.方法 选取自2014年2月～2015年4月期间,新疆维吾尔自治区伊犁州奎屯医院收治的79例肺叶切除的患者进行研究分析.采用双盲、随机的方法将所有患者分为对照组39例和观察组40例.对照组患者采用单独应用地佐辛注射液进行术后镇痛,观察组患者采用地佐辛联合正清风痛宁片进行术后镇痛治.结束治疗后,对2组患者的视觉模拟评分(VAS评分)、数字镇静评分(NSS评分)、心率(HR) 、平均动脉压(MAP) 及心指数(CI)的变化以及不良反应情况进行对比分析.结果 ①治疗后,对2组患者术后VAS评分进行对比分析,结果显示,观察组患者术后6 h、术后12 h、术后24 h的VAS评分均低于对照组,差异有统计学意义(P＜0.05);②治疗后,对2组患者术后NSS评分进行对比分析,结果显示,观察组患者术后6 h、术后12 h、术后24 h的NSS评分均高于对照组,差异有统计学意义(P＜0.05);③对2组患者术中HR改变量、MAP改变量、CI改变情况进行比较,观察组的患者血流动力学指标波动明显小于对照组,差异有统计学意义(P＜0.05);④2组患者术中不良反应比例无统计学意义.结论 在地佐辛的基础上联合应用中药正清风痛宁片可减轻胸腔镜肺叶切除术后静脉镇痛程度,稳定患者血流动力学指标,其是一种安全且有效的治疗方法,应在临床中进行推广和使用.