理气定喘丸联合地塞米松治疗哮喘急性期的临床观察

摘要

目的 观察理气定喘丸联合地塞米松治疗哮喘急性期的临床疗效.方法 选取2015年7月～2016年9月杭州市肿瘤医院收治的哮喘急性期患者93例,按随机数字表法分为对照组46例和观察组47例.对照组患者给予应用地塞米松进行治疗,观察组在对照组常基础上加用理气定喘丸联合治疗,记录并分析2组患者治疗后主要症状消失时间、1秒钟用力呼气容积(FEV1)、呼气高峰流速值(PEF)、超敏-C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)以及治疗后临床疗效.结果 ①观察组患者治疗后喘息咳嗽、胸闷和哮鸣音消失时间分别为(4.71±0.59)d、(2.85±0.49)d、(4.93±0.70)d,均短于对照组(7.76±1.02)d、(5.16±0.74)d、(8.67±1.12)d,且差异均具有统计学意义(P＜0.05);②治疗后观察组FEV1和PEF值分别为(65.69±3.74)V/L、(218.92±16.09)L/s,均优于对照组(57.45±3.62)V/L、(176.34±15.14)L/s,且差异均具有统计学意义(P＜0.05);③观察组治疗后hs-CRP和TNF-α值分别为(6.76±0.78)mg/L、(7.99±1.87)pg/mL,均低于对照组(6.76±0.78)mg/L、(7.99±1.87)pg/mL,且差异均具有统计学意义(P＜0.05);④治疗后观察组总有效率为91.49%,显著高于对照组71.74%,且差异均具有统计学意义(P＜0.05).结论 理气定喘丸联合地塞米松治疗对哮喘急性期有良好的治疗作用,可缩短哮喘相关症状、降低患者炎症水平,优化患者1秒钟用力呼气容积和呼气高峰流速值,联合用药效果优于单独用药.%Objective To observe the clinical efficacy of LiQiDingChuan pill combined with Dexamethasone on the treatment of patients with acute asthma.Methods 93 patients with acute asthma from July 2015 to September 2016 were randomly divided into the observation group(47 cases)and the control group(46 cases).The control group were received dexamethasone, and the observation group were given LiQiDingChuan pill combined with Dexamethasone.The main symptoms disappeared time, forced expiratory volume in 1 second, peak expiratory flow rate value, hs-CRP, TNF-α and clinical efficacy were recorded and analyzed.Results ①After treatment, wheezing cough, chest tightness and wheezing disappeared time were(4.71±0.59)d,(2.85±0.49)d,(4.93±0.70)d in the observation group, which were shorter than(7.76±1.02)d,(5.16±0.74)d,(8.67±1.12)d in the control group, and the differences were statistically significant(P<0.05).② After treatment, FEV1 and PEF levels were(65.69±3.74)V/L,(218.92±16.09)L/s, which were better than(57.45±3.62)V/L,(176.34±15.14)L/s in the control group, and the differences were statistically significant(P<0.05).③ After treatment, hs-CRP and TNF-α levels were(6.76±0.78)mg/L,(7.99±1.87)pg/mL, which were better than(6.76±0.78)mg/L,(7.99±1.87)pg/Ml in the control group, and the differences were statistically significant(P<0.05).④The total effective rate in the observation group was 91.49%, which was significantly higher than 71.74% in the control group, and the differences were statistically significant(P<0.05).Conclusion Liqidingchuan pills combined with dexamethasone treatment has a good therapeutic effect on acute phase of asthma, which can reduce asthma related symptoms, reduce the inflammation level in the patients, optimize the forced expiratory volume in 1 second and peak expiratory flow rate.The combination is better than the single drug.