Effect of inhalant combined with Dingchuan Zhike decoction therapy on the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with cough variant asthma

摘要

Objective: To study the effect of inhalant combined with Dingchuan Zhike decoction therapyon the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with coughvariant asthma. Methods: A total of 60 patients with cough variant asthma who were treatedin our hospital between January 2014 and May 2016 were collected and divided into thecontrol group (n=30) who received conventional inhalant treatment and the observation group(n=30) who received inhalant combined with Dingchuan Zhike decoction treatment accordingto single-blind randomized controlled method, and the treatment lasted for 6 months. Beforetreatment and after 6 months of treatment, high-resolution CT was used to determine theairway remodeling index levels, RIA method was used to detect the peripheral blood airwayremodeling index contents, and enzyme-linked immunosorbent assay (ELISA) was used todetect the contents of inflammatory mediators in induced sputum and the PARC/CCL-18 inserum. Results: Before treatment, the differences in the airway remodeling degree as well asthe contents of inflammatory mediators and PARC/CCL-18 were not statistically significantbetween the two groups. After 6 months of treatment, CT airway remodeling indexes LA andTA levels of observation group were higher than those of control group while WA level waslower than that of control group, and peripheral blood airway remodeling indexes CTGF, YKL-39, MMP-9 and TIMP-1 contents were lower tha=n those of control group; inflammatorymediators IL-5, IL-6 and IL-8 contents in induced sputum of observation group were lowerthan those of control group, and serum PARC/CCL-18 content was lower than that of controlgroup. Conclusion: Inhalant combined with Dingchuan Zhike decoction can inhibit the airwayremodeling and reduce the airway inflammation in patients with cough variant asthma.