抗生素及外敷九一丹联合切开挂线术对肛周脓肿患者血清ACTA和CRP表达的影响研究

摘要

目的 探讨抗生素和外敷九一丹联合切开挂线术对肛周脓肿患者血清激活素A(activin A, ACTA)和C反应蛋白(C-reactive protein, CRP)表达水平的影响作用.方法 选择绍兴文理学院附属医院2015年3月~2016年12月普外科收治的120例肛周脓肿患者作为研究对象,采取随机数字法分为实验组和对照组,每组各60例.2组患者均接受切开挂线术,术后实验组患者注射抗生素和外敷九一丹,对照组患者仅注射抗生素.观察2组患者治愈率、6个月后复发率、创面平均愈合时间、创缘水肿率,检测分析2组患者术前7d、术后3d、7d、14d的血清ACTA和CRP表达水平.结果 实验组患者治愈率96.7%高于对照组(P<0.05),实验组患者复发率低于对照组,差异性无统计学意义;实验组患者平均愈合时间为(20.67±3.22)d,短于对照组患者平均愈合时间(29.48±3.15)d,实验组患者创缘水肿率5%显著小于对照组20%(P<0.05);2组患者术后3d的ACTA、CRP表达水平均显著高于术前7d表达水平(P<0.05);术后7d,2组患者的ACTA、CRP表达水平均显著低于术前7 d表达水平(P<0.05),实验组患者ACTA水平显著低于对照组患者,差异有统计学意义(P<0.05);术后14d,2组患者ACTA水平显著低于术前表达水平(P<0.05).结论 一线切开挂线术联合外敷九一丹可有效治疗肛周脓肿,降低ACTA和CRP表达水平,缓解术后炎症反应,值得临床推广.%Objective To explore influence of antibiotics and Jiuyi Dan combined with incision-thread-drawing procedure on perianal abscess patients' level of activin A (ACTA) and C-reactive protein (CRP).Methods120 cases of perianal abscess patients in our hospital during March 2015 to December 2016 Coloproctology were selected, they were divided into the experiment group and the control group by random number method.All of patients were taken incision-thread-drawing procedure.Then the experimental group were given nine one antibiotics and Jiuyi Dan, the control group were given antibiotics.The cure rate, 6months after the recurrence rate, average healing time of the wound, and wound edema rate of two groups were observed.Levels of ACTA and CRP expression levels of two groups of patients before and after operation were analyzed.ResultsPatients in the experimental group cure rate was 96.7% higher than that of the control group (P<0.05), the recurrence rate of patients in the experimental group than in the control group, the difference was not statistically significant;the patients in the experimental group the average healing time was (20.67±3.22) d shorter than the average healing time of patients in the control group (29.48±3.15) d, patients in the experimental group wound edema rate of 5% was significantly lower than in the control group 20% (P<0.05);3D ACTA, the expression level of CRP was significantly higher than the preoperative 7 d levels after operation in the two groups (P<0.05);after 7d, the expression level of the two groups of patients with ACTA and CRP were significantly lower than the preoperative level of expression of 7d (P<0.05), experimental group levels of ACTA were significantly lower than the control group, the difference was statistically significant (P<0.05);postoperative 14d patients, ACTA levels of two groups were significantly lower than the levels before operation (P<0.05).ConclusionPerianal abscess can be treated effectively and patients levels of Acta and CRP were obviously dereased by Jiuyi Dan combined with incision-thread-drawing procedure combined, postoperative inflammatory reaction could be importantly alleviated, it was worth clinical promotion.