Objective To explore the effects of nifedipine combined with Magnesium Sulfate on the serum of patients with hypertension of pregnancy blood creatinine, uric acid and serum cystatin C level.Methods68 cases of patients with pregnancy induced hypertension from December 2013 to December 2015 in our hospital were selected, according to the different treatment methods were divided into control group and experimental group, 34 cases in each group, the two groups were treated with conventional therapy and symptomatic treatment, the control group was given 25% Magnesium Sulfate Injection 20mL+5%, Glucose Injection 20mL, 8~10min intravenous injection, after 25% Magnesium Sulfate Injection 60mL+5% Glucose Injection 500mL intravenous drip, 1~2g/L,1 times a day, Phentolamine Mesilate Injection 20mg+5%, Glucose Injection 250mL intravenous drip, 30min drop, 1 times a day;The experimental group was given the Extended Release Nifedipine Tablets 30mg sublingual in the control group on the basis of 3 times a day.Two group of gestational age<38 weeks treatment time was seven days,, the end of pregnancy over 38 weeks of treatment time was three days.After treatment the clinical efficacy, serum creatinine, uric acid, cystatin C, alpha-fetoprotein and adverse pregnancy outcome were compared between the two groups.ResultsAfter treatment,compared with the control group, the total effective rate of treatment group was higher (P<0.05), 2 groups of the blood serum uric acid, creatinine, Cystatin C and AFP levels were decreased (P<0.05), compared with the control group, the experimental group of serum uric acid, serum creatinine, Cystatin C and alpha fetoprotein level was lower (P<0.05).The experimental group, the complication rate was 5.88%, incidence rate of complications in the control group 14.71%, 2 groups of adverse pregnancy outcome rate comparison, the difference was not statistically significant.ConclusionNifedipine combined with Magnesium Sulfate significantly on clinical efficacy in patients with pregnancy induced hypertension, decrease the level of serum creatinine, uric acid and serum cystatin C levels, improve the quality of pregnancy, drug safety is high.%目的 探究硝苯地平联合硫酸镁对妊娠高血压患者血清血肌酐、尿酸及胱抑素C水平的影响.方法 收集2013年12月~2015年12月台州第一人民医院妇产科收治的妊娠高血压患者68例,根据治疗方法不同分为对照组和试验组,每组34例,2组均实施常规治疗以及对症治疗,对照组给予25%硫酸镁注射液20mL+5%葡萄糖注射液20mL,8~10min静脉推注,后给25%硫酸镁注射液60mL+5%葡萄糖注射液500mL静脉滴注,1~2g/L,每天1次,甲磺酸酚妥拉明注射液20mg+5%葡萄糖注射液250mL静脉滴注,30min滴完,每天1次;试验组在对照组的基础上给予硝苯地平缓释片30mg舌下含服,每日3次.2组患者中孕周<38周治疗时间为7天,孕周≥38周治疗时间3天.治疗结束后对比分析2组患者临床疗效、血肌酐、尿酸、胱抑素C、甲胎蛋白以及不良妊娠结局发生率.结果 治疗后与对照组相比,试验组临床总有效率较高(P<0.05),治疗后2组血清血肌酐、尿酸、胱抑素C以及甲胎蛋白水平降低(P<0.05),与对照组相比,试验组血清血肌酐、尿酸、胱抑素C以及甲胎蛋白水平均明显更低(P<0.05).试验组并发症发生率为5.88%,对照组发症发生率为14.71%,2组不良妊娠结局发生率比较,差异无统计学意义.结论 硝苯地平联合硫酸镁对妊娠高血压患者的临床疗效显著,下调血清血肌酐、尿酸及胱抑素C水平,提高妊娠质量,药物安全性较高.
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