胃复安联合膳食改善对治疗ICU患者晚期胃癌化疗患者免疫功能及生活质量的影响

摘要

目的 探讨胃复安联合膳食改善对治疗ICU患者晚期胃癌化疗患者免疫功能及生活质量的影响.方法 回顾性分析天台县人民医院70例Ⅲ~Ⅳ期晚期胃癌患者临床病历资料与治疗情况;按照随机数字表法将其分为对照组(采用OLF方案化疗治疗)与观察组(化疗联合胃复安联合膳食改善),各35例,统计2组治疗4个疗程后临床疗效及不良反应情况,用卡氏生活质量(KPS)评分评价2组患者治疗前、后生存质量;检测2组患者治疗前后免疫功能.结果 观察组临床疾病控制率68.57%与对照组60.0%比较差异无统计学意义;观察组与对照组治疗后KPS评分,明显高于治疗前,且观察组KPS评分明显高于对照组,差异有统计学意义(P<0.05).2组治疗前各项免疫功能指标相比较差异无统计学意义;对照组CD4+细胞、CD4+/CD8+及NK细胞水平较治疗前明显下降,差异有统计学意义(P<0.05);且与观察组比较(P<0.05).观察组不良反应率37.14%明显低于对照组68.57%,差异有统计学意义(P<0.05).结论 胃复安联合膳食改善可减少不良反应,有助于改善患者免疫功能及生活质量.%Objective To investigate the effect of Weifu'an combined with dietary improvement on immune function and quality of life in patients with advanced gastric cancer chemotherapy.MethodsAnalysis of hospital, 70 cases of Ⅲ~Ⅳ period clinical medical records and treatment in patients with advanced gastric cancer;According to random number table method will be divided into the control group (chemotherapy using OLF) and observation group (chemotherapy combined Weifu'an combined dietary improvement), and 35 cases statistics of two groups of clinical curative effect and adverse reactions after the treatment of four course, carr's quality of life (KPS) score was used to ealuate treatment in both groups before and after the survival quality.Detection in the two groups before and after treatment in patients with immune function.ResultsThe control rate of clinical disease was 68.57% in the observation group and 60.0% in the control group, there was no significant differemce.The KPS score of the observation group and the control group was significantly higher than that of the control group before the treatment and the KPS score of the observation group was significantly higher than that of the control group(P<0.05).Compared with the observation group, the levels of CD4+/CD8+ and NK cells in the control group were significantly lower than those in the control group, the difference was statistically significant (P<0.05).The adverse reaction rate was 37.14% in the observation group and 68.57% in the control group,the difference was statistically significant(P<0.05).ConclusionWeifu'an combined dietary improvement can reduce adverse reactions, immune function and help to improve the patients quality of life.