盐酸氨溴索对重症肺炎TNF-α、hs-CRP等炎症因子水平变化的影响及临床疗效分析

摘要

目的 探讨盐酸氨溴索对重症肺炎的治疗效果及对TNF-α、hs-CRP等炎症因子水平的影响.方法 回顾性分析2014年12月~2016年8月在宁波市医疗中心李惠利医院接受治疗的重症肺炎患者的临床资料,根据其治疗方式分为对照组和观察组,对照组给予常规治疗,观察组在常规治疗的基础上给予盐酸氨溴索治疗.观察2组患者的治疗效果,比较2组患者治疗前后血清炎症细胞因子水平、肺功能、咳嗽咳痰症状积分的差异.结果 观察组治疗的有效率为97.50%,明显高于对照组;2组患者治疗前血清炎症细胞因子水平无差别,治疗后,观察组IL-6、IL-8、hs-CRP和TNF-α水平均低于对照组;2组患者治疗前肺功能指标无差别,治疗后,观察组FVC、FEV1和FEV1/FVC水平均高于对照组;治疗前2组患者症状积分无差别,治疗后,观察组咳嗽、痰量、咳嗽难易程度和哮鸣音得分均低于对照组.结论 盐酸氨溴索对重症肺炎有较好的治疗效果,可明显降低患者TNF-α、hs-CRP等炎症细胞因子水平,改善相关症状,具有良好的应用价值.%Objective To investigate the therapeutic effect of ambroxol hydrochloride on severe pneumonia, and the influence on the inflammatory cytokines of TNF-alpha and hs-CRP etc.MethodsThe clinical data of severe pneumonia patients treated in ningbo city medical treatment center Lihuili hospital from December 2014 to August 2016 were retrospectively analyzed.According to the treatment methods are divided into control group and observation group, the control group was given routine treatment, the observation group in the conventional treatment based on the given of ambroxol hydrochloride.To observe the therapeutic effect of two groups, the differences of serum levels of inflammatory cytokines, pulmonary function, cough and expectoration symptom scores of the two groups were compared before and after treatment.ResultsThe effective rate of the observation group was 97.50%, which was significantly higher than that of the control group;Two groups of patients before treatment serum inflammatory cytokines level no difference, after treatment, the observation group IL-6, IL-8, hs-CRP and TNF-alpha water average lower than the control group;Two groups of patients before treatment pulmonary function index no difference, after treatment, the observation group FVC, FEV1 and FEV1/FVC levels were higher than the control group;Two groups of patients with symptoms of no difference before treatment after treatment, observation group cough, sputum volume, cough ease and wheezing scores were lower than the control group.ConclusionAmbroxol hydrochloride has a good therapeutic effect on severe pneumonia can be significantly reduced in patients with TNF-hs-CRP alpha, inflammatory cytokine levels, improve the symptoms and signs, has good application value.