腺性膀胱炎患者电切术后辅以药物膀胱灌注治疗临床疗效及对患者SAS、QOL的影响

摘要

目的 探讨腺性膀胱炎患者行电切术后辅以药物膀胱灌注治疗临床效果,并观察其对患者焦虑(SAS)及生活质量指数(QOL)的影响.方法 回顾性分析2011年1月～2016年12月期间于宁波市北仑区人民医院入院治疗的62 例腺性膀胱炎患者临床诊治情况,其中以单纯等离子电切术治疗者为对照组,以等离子电切术+康复新液联合吉西他滨膀胱灌注治疗者为治疗组,每组各31 例.统计2 组患者临床疗效,随访12 个月,并采用焦虑自评量表(SAS)评价2 组患者治疗前、治疗后12月时焦虑情况;采用QOL评价2 组患者治疗前、治疗后12月时生活质量情况.记录2 组治愈后复发人数.结果 治疗后,治疗组治疗有效率为80.65％,略高于对照组77.42％,差异有统计学意义( P<.0.05);治疗组SAS评分略高于治疗前,但差异无统计学意义;对照组治疗后SAS评分较治疗前显著下降,治疗后组间比较,差异有统计学意义( P<.0.05);治疗组患者术后QOL指数较治疗前略下降,但差异无统计学意义;对照组治疗后QOL指数较治疗前明显下降,且治疗后2组间相比较,差异有统计学意义( P<.0.05).随访12个月,治疗组复发率11.11％,略低于对照组18.75％,差异有统计学意义( P<.0.05).结论 相比单纯等离子电切术来说,采用术后辅以药物行膀胱灌注治疗腺性膀胱炎效果与其相当,但后者可能会增加患者焦虑程度,从而影响患者生活质量,因此对于非必须采用药物治疗者来说,可优先考虑单纯手术治疗.%Objective To investigate the clinical effects of transurethral resection of cystitis after gynecological cystitis after transurethral resection of bladder,and to observe the effect on patients' anxiety(SAS)and quality of life index(QOL).Methods The clinical data of 62 patients with cystitis glandularis admitted to hospital from January 2011 to December 2016 were retrospectively analyzed.The control group was treated with plasma ablation alone,with plasmakinetic resection of Kangfuxin liquid combined with gemcitabine intravesical therapy as the treatment group,31 cases in each group.Statistics of two groups of patients with clinical efficacy,followed up for 12 months,and the anxiety self-rating scale(SAS)was used to evaluate the anxiety of the two groups before and after treatment,QOL was used to evaluate the quality of life before and after treatment in two groups of patients.The recurrence rate of two groups were recorded.Results After treatment,the effective rate of the treatment group was 80.65％,slightly higher than the control group 77.42％,the difference was statistically significant(P<0.05),the SAS score in the treatment group was slightly higher than before treatment,but the difference was not statistically significant,the SAS score in the control group was significantly lower than before treatment,after treatment between the groups,the difference was statistically significant(P<0.05).The QOL index of the treatment group decreased slightly after treatment,but the difference was not statistically significant.The QOL index of the treatment group decreased significantly after treatment,and compared between the two groups after treatment,the difference was statistically significant(P<0.05).Follow-up of 12 months,the relapse rate in the treatment group was 11.11％,slightly lower than the control group 18.75％,the difference was statistically significant(P<0.05).Conclusion Compared to pure plasmapheresis,the use of postoperative intravesical instillation of bladder irrigation with the same effect,but the latter may increase the degree of anxiety in patients,thus affecting the quality of life of patients,so for the non-mandatory use of drugs treatment,surgery may be given priority to surgery alone.