丙种球蛋白联合糖皮质激素冲击疗法治疗小儿难治性支原体肺炎患者血清CRP的影响及安全性

摘要

Objective To investigate the effect of gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with refractory mycoplasma pneumonia in CRP and safety.Methods 46 cases of children with refractory mycoplasma pneumonia from February 2012 to February 2016 were selected and randomly divided into the control group and experimental group,23 cases in each group.On the basis of the regular treatment,the control group was given azithromycin,10mg/kg,qd,intravenous drip,on the basis of the control group treatment,the experimental group was treated with methylprednisolone 2mg/kg+human immunoglobulin 400mg/kg,qd,intravenous drip.The levels of serum C-reactive protein(CRP),white blood cell count(WBC),lymphocyte count(LC),therapeutic efficiency and safety were measured before and after treatment.Results After treatment,compared with the control group,the serum levels of CRP、WBC、LC were lower in the experimental group,the difference was statistically significant(P<0.05).The treatment efficiency of the experimental group(91.31％)was significantly higher than that of the control group(65.22％),the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The gamma globulin combined with glucocorticoid pulse therapy can significantly reduce the serum levels of CRP,WBC and LC in children with refractory mycoplasma pneumonia,improve clinical efficacy and the safety were good.%目的 探讨丙种球蛋白联合糖皮质激素冲击疗法对小儿难治性支原体肺炎患者血清C 反应蛋白(CRP)影响及安全性.方法 选取2012年2月～2016年2月于宁波市北仑区中医院进行治疗的46 例难治性支原体肺炎患儿,随机分为对照组及试验组,每组各23 例;在常规治疗基础上,对照组给予阿奇霉素,10 mg/kg,qd,静滴;试验组在对照组基础上给予甲强龙2 mg/kg +人免疫球蛋白400 mg/kg,qd,静滴.比较2 组患儿治疗前后血清CRP、白细胞计数(WBC)、淋巴细胞计数(LC)水平、治疗有效率及安全性.结果 治疗后,与对照组比较,试验组患儿血清CRP、WBC、LC 水平较低,差异有统计学意义(P<.0.05).2组患儿不良反应发生率比较差异无统计学意义.结论 丙种球蛋白联合糖皮质激素冲击疗法能够明显降低小儿难治性支原体肺炎患儿的血清CRP、WBC、LC水平,提高临床疗效,且安全性较好.