肺癌组织中BRCA1蛋白表达与患者化疗疗效的关系研究

摘要

目的 探讨肺癌组织中BRCA1蛋白表达水平与吉西他滨联合顺铂化疗效果及预后的关系.方法 选择2013年5月~2015年5月期间在桐庐第一人民医院经病理证实为鳞癌的晚期肺癌患者80例,均接受吉西他滨联合顺铂化疗,及参芪扶正液辅助治疗.检测所有患者肺癌组织中BRCA1蛋白表达,探讨其与肺癌化疗效果及患者预后的关系.结果 80例患者中BRCA1蛋白阳性40例,阴性40例,BRCA1阳性表达的患者CR5例、PR6例,缓解率明显低于BRCA1阴性表达的患者(P<0.05).80例患者主要出现的不良反应为白细胞减少、胃肠道症状(恶性呕吐)、肝功能异常、外周神经毒性,BRCA1表达阳性的患者并发症的发病率均明显高于BRCA1表达阴性的患者(P<0.05).N分期(P=0.03)、BRCA1基因阳性(P=0.02)是影响肺癌患者预后的独立危险因素.结论 肺癌组织中BRCA1蛋白阳性患者化疗效果差,不良反应多,预后差.%Objective To investigate the relationship between BRCA1 protein expression in lung cancer tissues and the effect of gemcitabine and Cisplatin based chemotherapy.Methods 80 cases of squamous cell carcinoma confirmed by pathology from May 2013 to May 2015 were selected, and treated with gemcitabine plus cisplatin chemotherapy and Ginseng and Astragalus assisted theropy.BRCA1 protein expression of all patients were detected, and relationship between the effect of chemotherapy and prognosis of patients with BRCA1 protein expression in lung cancer tissues were studied.Results In 80 cases, BRCA1 protein was positive in 40 cases, 40 cases were negative, CR 5 patients, PR 6 patients with BRCA1 positive expression, the remission rate was lower than the BRCA1 negative patients ( P <0.05 ) .80 cases of adverse reactions were seen as leukopenia, gastrointestinal symptoms (nausea and vomiting), abnormal liver function, BRCA1 expression of peripheral neurotoxicity, the incidence of complications in patients with positive expression were significantly higher than BRCA1 negative patients(P<0.05).N stage (P=0.03), BRCA1 gene (P=0.02) were independent risk factors of the prognosis of patients.Conclusion BRCA1 protein positive patients in lung cancer tissue had poor chemotherapy effect, more adverse reactions, and poor prognosis.