美托洛尔联合贝那普利治疗对老年高血压合并心力衰竭患者治疗的心脏结构及心功能的影响

摘要

目的 研究美托洛尔联合贝那普利治疗对老年高血压合并心力衰竭患者治疗的心脏结构及功能的影响.方法 120例老年高血压合并心力衰竭患者按照随机数表的方法,分为联合组和对照组.2组均给予对症支持基础治疗,对照组在常规治疗基础上应用降压药物贝那普利对患者进行治疗;联合组在对照组治疗的基础上,应用美托洛尔进行联合治疗.治疗后,对疗效进行评估.并在治疗前后,记录分析2组患者的心脏结构变化状况,并对血压、心功能状况.结果 联合组的总有效率为91.67%,对照组为78.33%,2组疗效有显著性差异(χ2=4.1830,P=0.0408).治疗6个月后,2组患者血压、心脏结构及6min步行距离均明显改善(P<0.05);联合组患者的血压、心脏结构及6min步行距离明显优于对照组(P<0.05).联合组患者并发症发生率为8.33%,对照组为13.33%,2组比较差异无统计学意义(χ2=0.7764,P=0.3782).结论 美托洛尔联合降压治疗可显著提高治疗的临床疗效,改善心脏结构及功能.%Objective To study the effect of metoprolol combined with benazepril on cardiac structure and heart function in patients with heart failure and the treatment of hypertension in the elderly. Methods 120 cases of elderly hypertensive patients with heart failure from June 2011 to June 2015 were studied, according to the random number table method, they were randomly divided into combination group and control group.The two groups were given symptomatic and supportive therapy, the control group on the basis of conventional treatment were given antihypertensive drugs of benazepril; combination treatment group were given metoprolol on the basis of control group. After treatment, the clinical efficacy of the two groups were evaluated, the changes of cardiac structure in the two groups were recorded and analyzed before and after treatment, and the blood pressure and cardiac function were analyzed. Results The total effective rate of the combined group was 91.67%, the control group was 78.33%, there was significant difference between the two groups (χ2=4.1830, P=0.0408). After 6 months of treatment, the blood pressure, cardiac structure and 6min walking distance were significantly improved in the two groups (P<0.05). The above indicators in combination group were significantly better than those in the control group (P<0.05). The complication rate in combination group was 8.33%, 13.33% in the control group, there was no statistically significant between two groups (χ2=0.7764, P=0.3782). Conclusion Metoprolol combined with antihypertensive treatment can significantly improve the clinical efficacy of the treatment, improve the cardiac structure and function.