3,5-二碘水杨醛缩水杨酰肼Schiff碱及其金属配合物的合成与抑菌活性

摘要

以吡啶、DMF为溶剂合成了3,5-二碘水杨醛缩水杨酰肼Schiff碱的过渡金属配合物,用紫外可见光谱、红外光谱、TG-DTA、元素分析及摩尔电导率对配合物进行了表征,推测了配合物的可能结构,并对结构特征进行了分析.应用紫外光谱和荧光光谱测定方法研究了配合物与ct-DNA的作用,发现这些配合物均以插入方式与ct-DNA作用.另外,对各配合物作了活性测试,发现它们对阴离子超氧自由基O2-和藤黄微球菌有良好的抑制作用.%Four coordination compounds of transition metal with 3,5-diiodo-salicylalidehyde and salicyhydrazide Schiff base have been synthesized in pyridine and DMF solvents. These ligand and complexes were characterized by UV and IR spectra, TG-DTG, elemental analysis, and molar conductance analysis. The interactions of the complexes with DNA were investigated by UV and fluorescence spectroscopies, which show that the binding mode of the complexes with ct-DNA was intercalation. In addition, the biological activity test reveals that the complexes have potentially catalytic and antibacterial activity towards superoxide anion radical O2" and Micrococcus luteus.