手性联二萘酚衍生物催化的苯乙炔与苯甲醛不对称加成反应

摘要

Chiral 3,3'-substituted 1 ,1'-bi-2-napthol(BIN0L) derivatives were synthesized from BINOL. The asymmetric addition of phenylacetylene and benzaldehyde in the presence of the BINOL derivative and diethyl zinc afforded the corresponding propargylic alcohols with 73％ yield and 40％ enatiomeric excess.%以手性联二萘酚为原料,合成了3,3'位取代的手性联二萘酚衍生物,研究了该衍生物配体在二乙基锌存在下,催化苯乙炔与苯甲醛的不对称加成反应,产物的产率为73%,e.e.值为40%.研究结果表明,手性联二萘酚衍让物结构的微小变化导致催化产物构型的改变.