高效液相色谱-串联质谱法测定润滑剂中的全氟有机化合物

摘要

An analytical method based on high-performance liquid chromatography tandem mass spectrometry has been developed for the determination of ,10 perfluorinated compounds. Various lubricant samples were extracted with the solvent. Then the extract was cleaned up by Oasis WAX and Envi-carb solid phase cartridge. Qualitative and quantitative analyses were carried out for the analyte under the multiple reaction monitoring(MRM) mode after the chromatographic separation over Waters Xbridge C18 (150 mm ×2. 1 mm, 3.5 μm) column. The limits of detection for 10 perfluorinated compounds were 0.001 ~ 0.005 mg/kg. Themean recoveries at the three spiked levels were 79.05% ~ 106. 26% , with the intra-day precision less than10% and the inter-day precision less than 20% .%建立了测定润滑剂中10种全氟有机化合物的高效液相色谱-串联质谱(HPLC-MS/MS)分析方法.不同类型的润滑剂样品经溶剂提取后,采用弱阴离子交换柱和石墨化碳柱净化,经C18色谱柱分离后进行HPLC -MS/MS多反应监测模式下的定性及定量分析.10种全氟有机化合物的方法检出限为0.001 ～0.005 mg/kg;在低、中、高的3个添加水平范围内的平均回收率在79.05％～106.26％;日内精密度均小于10％,日间精密度均小于20％.