(S)-3-Chloro-l-phenyl-l-propanol was synthesized asymmetrically by using catalysts (R)-α,α-diphenyl-2-pyrrolidinemethanol, ( 1R, 2S)-2-amino-l, 2-diphenylethanol and ( 1R, 2R)-l-amino-2-indanolwith amine borane complexes, with a yield of 88. 3% ~ 93. 8% , ee% 81.6 ~ 87. 7. These amine boranecomplexes are more stable and safe than the borane-tetrahydrofuran complex and borane-methyl sulfidecomplex.%分别以R-α,α-二苯基脯氨醇、(1R,2S)-2-氨基-1,2-二苯基乙醇和(1R,2S)-(-)-1-氨基-2-茚醇为催化剂,以多种硼烷胺配合物为还原剂,由β-氯代苯乙酮不对称合成(S)3-氯-1-苯基-1-丙醇,收率88.3% ~93.8%,e.e.值为81.6%~87.7%.用硼烷胺配合物代替硼烷-THF和硼烷二甲硫醚,稳定性好,容易计量和安全操作.
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