抗结核组合药对HBVM阳性肺结核病人肝功能影响的观察

摘要

目的　观察抗结核组合药对HBVM阳性肺结核病人肝功能的影响。方法　比较HBVM阳性和阴性肺结核病人组合药治疗前后肝功能损害情况。结果　HBVM阳性病人肝损率比阴性者明显增高(P<0.01)；其中“模式Ⅰ”与“模式Ⅱ”病人肝损率差异不显著(P>0.05)，而“模式Ⅰ+Ⅱ”病人肝损率比“模式Ⅲ”高(P<0.05)。结论　组合药致肝功能损害，HBVM阳性病人比阴性多见，尤以“模式Ⅰ、Ⅱ”病人更易发生，可能与用药前肝脏病理损害严重程度有关。应慎用组合药并积极采取综合措施防范。%Objective　To observe the effect on liver function in pulmonary tuberculosis with positive HBVM treated by antituberculotic combination.Methods　Compare the damage to the liver function of the HBVM positive or negative tuberculosis patient before and after taking the antituberculotic combination.Results　The damage to the liver function of the HBVM positive tuberculosis patient is much higher than negative tuberculosis patient(P<0.01),and the damage to the “Model-Ⅰ”and “Model-Ⅱ”patient varies little(P>0.05).But the damage to the liver function of “Model-Ⅰ+Ⅱ”patients is higher than that of “Model-Ⅲ”(P<0.05).Conclusion　The antituberculotic combination will damage the liver function of HBVM positive tuberculosis patients and negative tuberculosis patients,“Model-Ⅰ”and “Model-Ⅱ”patients are easily affected.The combination drug must be taken carefully and comprehesive prevention measures must be taken ahead.