莫西沙星与左氧氟沙星治疗AECOPD的对比研究

摘要

目的 观察莫西沙星注射液治疗慢性阻塞性肺疾病急性发作(AECOPD)的疗效、副作用和具体用药方法。方法 收集住院的AECOPD患者113例，随机分成两组，分别以莫西沙星和左氧氟沙星(对照组)治疗，比较两组治疗后的疗效、细菌清除率及对预后指标(FEV1、呼吸困难、6min步行距离)的改善率及药物副作用；同时将莫西沙星治疗组随机分为持续静脉滴注组和静滴加口服序贯治疗组，比较两组治疗后的疗效、细菌清除率及对预后指标(FEV1、呼吸困难、6min步行距离)的改善率。结果 莫西沙星治疗组的临床有效率(77.78％)、细菌清除率(81.48％)及对三项预后指标的改善率(82.54％、73.02％、69.84％)均高于左氧氟沙星组，而药物副作用发生率两组相当。莫西沙星持续治疗组与序贯治疗组比较，临床有效率、细菌清除率及对三项预后指标的改善率均无明显差异。结论 莫西沙星用于治疗AECOPD优于左氧氟沙星，且持续静滴给药治疗AECOPD与序贯给药比较无优势，从经济学角度，应推荐序贯给药治疗。%Objective To observe the curative effects and side effects and administration of moxifloxacin injection when used to treat acute explosion chronic obstructive pulmonary disease(AECOPD). Methods 113 hospitalized patients of AECOPD were collected and randomizedly divided into two groups and were treated with moxifloxacin or levofloxacin respectivly. The efficacy rates, bacteriums eradication rates and the side effects of two groups were compared. And the improvement rates of FEV1 or walking distance of 6min or dyspnea were also compared. Besides, the patients of AECOPD treated with moxifloxacin were randomizedly divided into two groups and treated with moxifloxacin injections continuously or moxifloxacin injections and tables sequently respetively. Similarly, the differents were compared between the two groups. Results The efficacy rates and bacterium eradication rates and the improvement rates of FEV1 or walking distance of 6min or dyspnea in moxifloxacin group were higher than those of levofloxacin group. But the rates of side effects were almost equal in two groups. The efficacy rates and bacterium eradication rates and the improvement rates of FEV1 or walking distance of 6min or dyspnea were nearly equal in the two groups of moxifloxacin. Conclusions Moxifloxacin injection is better than levofloxacin injection in treating AECOPD. And the method using moxifloxacin injections continuously is not better than that using moxifloxacin injections and tables sequently. The method of using moxifloxacin injections and tables subsequently should be recommended to use for its lower costs.